Large or Food Animal and Equine Medicine Commons^™

Ethyl Pyruvate Failed To Reduce Pro-Inflammatory Cytokines Release Following In Vitro Stimulation In Dairy Calves' Whole Blood., Vincent Dore

Doctoral Dissertations

Recent developments in sepsis treatment showed that control of the late mediator of inflammation, High Mobility Box group-1 (HMGB1), improves survival in animal models of endotoxemia. Ethyl pyruvate is a small-molecule inhibitor that has been shown to reduce the systemic release of HMGB1 during experimental treatment of systemic inflammation in different species. The objectives of this body of work were 1) to explore ethyl pyruvate's ability to modulate early pro-inflammatory cytokines production and immune effector function in treated calves, 2) to evaluate the safety of an administration of ethyl pyruvate infusion in neonatal calves, and 3) to explore ethyl pyruvate's …

Therapeutic Intervention Or Rider Influence On The Electromyographic Activity And Kinematics Of Horses, Karen L. Shaw

Masters Theses

Core strengthening and postural stability are desired outcomes of certain therapeutic exercises performed in horses. This study aimed to quantify changes in muscle activation at a walk and trot in horses traveling over eight consecutive ground poles evenly spaced (at 30 inches for walk and 48 inches for trot) in parallel fashion in a straight line, and with hindquarter and abdominal elastic resistance bands applied at 25% stretch. Surface electromyography (sEMG) data were collected for the longissimus dorsi and rectus abdominus muscles in six horses. A 2x2 repeated measures ANOVA was performed for each muscle to test for significant differences …

Therapeutic Exercise Influences On Activity Of The Multifidus Muscles In Horses, Tena L. Ursini

Doctoral Dissertations

Back pain is a worldwide debilitating condition that affects humans and animals alike. Lower back pain in humans can be caused by a myriad of conditions, including idiopathic origin. Spinal stability is compromised during disease, and a lack of stability also contributes to pathologic spinal conditions. Regardless of species, the stability of the spine depends on bones, ligaments, tendons and muscles. Muscles provide the only active component that can counteract various loads applied to the body. There are several muscle groups that contribute to spinal mechanics. The erector spinae group are large superficial muscles the lie along each side of …

Follicular Dynamics In Insulin Resistant Mares, Julio Cesar Prado

Masters Theses

Obesity and insulin resistance have been linked to prolonged interovulatory period, aberrations in the estrous cycle, and continuous reproductive activity during the non-breeding season. EMS has been determined to influence the intrafollicular environment of mare ovaries. In humans, insulin resistance has been linked to polycystic ovaries as part of Polycystic Ovarian Syndrome (PCOS). A study was conducted to determine 1) the impact of insulin resistance on follicle growth and size at ovulation, and 2) whether predicted ovulatory follicles respond to hCG administration in Insulin-resistant (IR) mares. Mares were selected for the study based on insulin sensitivity and separated into an …

How Microbiomes Can Feed The World: A Look Into Bovine Reproduction, Hannah Noel Mcdonald

Chancellor’s Honors Program Projects

No abstract provided.

Absorption And Utilization Of Choline And Vitamin B12 In Lactating Dairy Cows Using Different Delivery Methods, Virginia Maria Artegoitia Etcheverry

Doctoral Dissertations

Choline and vitamin B12 are essential nutrients for growth and performances of production animals. However, both nutrients are extensively degraded during digestion in the rumen. This thesis comprised three experiments. First, four cows equipped with a rumen cannula and catheters in the portal vein and a mesenteric artery received a post-ruminal bolus of: 1) cyanocobalamin (CN-CBL) alone (0.1 g) [gram], 2) CN-CBL (0.1 g) + casein (10 g) or 3) CN-CBL (0.1 g) + whey proteins (10 g). After the bolus, blood samples were taken until 24 h [hour] post-bolus. The intestinal absorption of CN-CBL was greater when the vitamin …

Differentiation Of Equine Mesenchymal Stromal Cells Into Cells Of Neural Lineage And Their Application Into A Novel Model For Acute Peripheral Nerve Injury In The Horse, Claudia Cruz

Masters Theses

Studies have shown that mesenchymal stromal cells (MSCs) are able to differentiate into extra-mesodermal lineages, including neurons. Positive outcomes were obtained after transplantation of neurally-induced MSCs in rats, rabbits and guinea pigs after nerve injury, but the effect of these cells is unknown in horses. Our objective was to test the ability of equine mesenchymal stromal cells to differentiate into cells of neuronal lineage, and to assess differences, if any, in morphology and protein expression. Additionally, we wanted to investigate if horse age and cell passage number contributed to the ability to achieve neural differentiation.

The first part of this …

The Spread And Potential Control Of Disease Across The Domestic Cattle-Wildlife Interface, Rachel Jackson

Chancellor’s Honors Program Projects

No abstract provided.

Biological Variation Of Thromboelastography Variables In Ten Healthy Female Horses, Jennifer Lee Scruggs

Masters Theses

Biological variability (BV) has important applications in laboratory medicine. It can be a source of variation in measured analyte values and provide guidance on reference interval use. BV has three components: between-individual variation (CVg), caused by differences in mean values of a particular analyte among members of a group, within-individual variation (CVi), caused by fluctuations around an individual’s inherent homeostatic set point, and analytical variation (CVa). Thromboelastography (TEG), a type of viscoelastic coagulation analysis, is becoming increasingly common in veterinary referral centers. Despite increased popularity, the optimal method of results interpretation is not clear. While population-based reference intervals (PRI) are …

Safety And Immunoreactivity Of A Xenogeneic Dna Plasmid Vaccine Expressing Human Tyrosinase In Tumor-Bearing Horses, Luis Miguel Lembcke Perez Prieto

Doctoral Dissertations

Melanomas are among the most common skin tumors in horses (second only to sarcoids), with prevalence rates reaching as high as 80% in adult gray horses. Despite the wide availability of measures of local control, there are currently no systemic therapies that can effectively prevent spread, or treat metastatic or locally advanced/non-resectable melanoma in horses. A form of gene immunotherapy based on a plasmid DNA construct containing a xenogeneic form of the antigen tyrosinase have been developed and optimized for targeting cancer in both humans and dogs; and have demonstrated significant immunoreactivity and clinical benefit in the treatment of melanocytic …

The Role Of Systemic Inflammation In The Development Of Equine Laminitis, Elizabeth Maryrose Tadros

Doctoral Dissertations

Laminitis is a crippling disease of horses that can result in chronic lameness and debilitation, and sometimes warrants euthanasia. It is a complication of inflammatory conditions such as gastrointestinal disease, and also occurs in obese, insulin-resistant horses with Equine Metabolic Syndrome (EMS). Inflammation and insulin resistance are risk factors for laminitis, and these mechanisms might converge to induce laminitis in susceptible animals.

Systemic inflammation is often attributed to endotoxemia, although circulating endotoxin concentrations are not commonly measured in the clinical setting. Although a theoretic basis exists for endotoxemia in the pathogenesis of laminitis, administration of endotoxin alone does …

Diagnosis And Management Of Horses With Equine Metabolic Syndrome (Ems), Kelly Ann Chameroy

Doctoral Dissertations

In horses, a painful and often debilitating disease known as laminitis can result in impaired function and, in severe cases, euthanasia. Equine Metabolic Syndrome (EMS) is a syndrome in horses that results in development of laminitis and is characterized by the presence of general and/or regional adiposity (“cresty neck”), aberrations in blood lipid concentrations, insulin resistance (IR) and/ or hyperinsulinemia. Therapies have focused on improving the state of obesity and insulin resistance with the goal of diminishing the likelihood of laminitis development. A definitive cause for laminitis has not been established, but hyperinsulinemia and IR are likely candidates as experimental …

Effects Of Pituitary Pars Intermedia Dysfunction (Ppid), Season, And Pasture Diet On Blood Adrenocorticotropic Hormone And Metabolite Concentrations In Horses., Sarah Beth Elliott

Masters Theses

Studies described in this thesis were performed to investigate associations among season, diet, pituitary pars intermedia dysfunction (PPID) and blood concentrations of adrenocorticotropic hormone (ACTH), insulin, glucose, and leptin in horses. In the first study, higher ACTH concentrations were detected in horses affected with PPID. A seasonal increase in plasma ACTH concentration was detected in the late summer and early fall, but PPID did not affect the timing or duration of this increase. Pasture grazing raised glucose and insulin concentrations with a peak in September, at the same time that horses had higher ACTH concentrations, and this convergence of risk …