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Fragile X

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Full-Text Articles in Occupational Therapy

Effects Of Sertraline Treatment For Young Children With Fxs, Andrew Ligsay, Laura Greiss Hess, Sarah Fitzpatrick, Kerrie Lemons Chitwood, Jonathan Polussa, Salpi Siyahian, Randi Hagerman Nov 2015

Effects Of Sertraline Treatment For Young Children With Fxs, Andrew Ligsay, Laura Greiss Hess, Sarah Fitzpatrick, Kerrie Lemons Chitwood, Jonathan Polussa, Salpi Siyahian, Randi Hagerman

Laura Greiss Hess

Selective serotonin reuptake inhibitors (SSRIs) help treat many of the phenotypic manifestations of fragile X syndrome (FXS) including anxiety, sensory processing challenges, and communication and intellectual deficits. However, the efficacy of SSRIs has not been previously studied in children with FXS under five-years-old. The purpose of this study was to elucidate group differences in behavior and developmental outcome measures for young children with FXS when treated with sertraline compared to placebo.

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Effects Of Sertraline Treatment For Young Children With Fxs, Laura Greiss Hess, Peter Mundy, Randi Hagerman Nov 2015

Effects Of Sertraline Treatment For Young Children With Fxs, Laura Greiss Hess, Peter Mundy, Randi Hagerman

Laura Greiss Hess

Phenotypic manifestations for young children with fragile X syndrome (FXS) include: anxiety, sensory processing challenges, global language and communication deficits and intellectual and developmental disabilities. Many of these symptoms can be treated with medications, including selective serotonin reuptake inhibitors (SSRIs). However to date a clinical trial has not been conducted for children under five years old. This study investigated the following question: Are there group differences on developmental outcome measures for those children treated with sertraline compared to placebo?

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Family Meanings, Contexts And Hopes Within A Clinical Trial, Laura Greis Hess, Cynthia Carter Ching, Randi Hagerman Nov 2015

Family Meanings, Contexts And Hopes Within A Clinical Trial, Laura Greis Hess, Cynthia Carter Ching, Randi Hagerman

Laura Greiss Hess

These qualitative analyses are a component of the clinical trial: “Effects of Sertraline Treatment for Young Children with FXS: Examination of Developmental Outcomes and Family Contexts.” We argue that inclusion of a sociocultural perspective within the context of a clinical trial affords consideration of: A dynamic view of development – simultaneous consideration of biological and sociocultural factors (Vygotsky, 1978). Application of a bioecological framework and consideration of ever changing nested settings and contexts over time (Bronfenbrenner, 2005)

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Effects Of Sertraline Treatment For Young Children With Fxs, Andrew Ligsay, Laura Greiss Hess, Sarah Fitzpatrick, Kerrie Lemons Chitwood, Jonathan Polussa, Salpi Siyahian, Randi Hagerman Oct 2015

Effects Of Sertraline Treatment For Young Children With Fxs, Andrew Ligsay, Laura Greiss Hess, Sarah Fitzpatrick, Kerrie Lemons Chitwood, Jonathan Polussa, Salpi Siyahian, Randi Hagerman

Collected Faculty and Staff Scholarship

Selective serotonin reuptake inhibitors (SSRIs) help treat many of the phenotypic manifestations of fragile X syndrome (FXS) including anxiety, sensory processing challenges, and communication and intellectual deficits. However, the efficacy of SSRIs has not been previously studied in children with FXS under five-years-old. The purpose of this study was to elucidate group differences in behavior and developmental outcome measures for young children with FXS when treated with sertraline compared to placebo.

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Ot, Slp, At & The Iep…Making Sense Of The Alphabet Soup, Laura Greiss Hess, Kerrie Lemons Chitwood Aug 2015

Ot, Slp, At & The Iep…Making Sense Of The Alphabet Soup, Laura Greiss Hess, Kerrie Lemons Chitwood

Laura Greiss Hess

Creating an IEP – or Individualized Educational Program – can be an incredibly confusing and daunting experience. The “alphabet soup” of acronyms and legalese often increases the anxiety and uneasiness for families. There are often many professionals in the room, some just popping in and out during the meeting, and families can feel isolated and not fully part of the process. One way to offset these feelings is to prepare ahead of time.

We’ve designed this article to be an at-a-glance format, combining our professional expertise and some handy resources. This information is presented via FAQs (more alphabet soup for …

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Effects Of Sertraline Treatment For Young Children With Fxs, Laura Greiss Hess, Peter Mundy, Randi Hagerman Jul 2014

Effects Of Sertraline Treatment For Young Children With Fxs, Laura Greiss Hess, Peter Mundy, Randi Hagerman

Collected Faculty and Staff Scholarship

Phenotypic manifestations for young children with fragile X syndrome (FXS) include: anxiety, sensory processing challenges, global language and communication deficits and intellectual and developmental disabilities. Many of these symptoms can be treated with medications, including selective serotonin reuptake inhibitors (SSRIs). However to date a clinical trial has not been conducted for children under five years old.

This study investigated the following question: Are there group differences on developmental outcome measures for those children treated with sertraline compared to placebo?

Go to article

Family Meanings, Contexts And Hopes Within A Clinical Trial, Laura Greis Hess, Cynthia Carter Ching, Randi Hagerman Jul 2014

Family Meanings, Contexts And Hopes Within A Clinical Trial, Laura Greis Hess, Cynthia Carter Ching, Randi Hagerman

Collected Faculty and Staff Scholarship

These qualitative analyses are a component of the clinical trial: “Effects of Sertraline Treatment for Young Children with FXS: Examination of Developmental Outcomes and Family Contexts.”

We argue that inclusion of a sociocultural perspective within the context of a clinical trial affords consideration of:

  • A dynamic view of development – simultaneous consideration of biological and sociocultural factors (Vygotsky, 1978).
  • Application of a bioecological framework and consideration of ever changing nested settings and contexts over time (Bronfenbrenner, 2005)

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Imitation In Fragile X Syndrome: Implications For Autism, Marta Macedoni-Luksic, Laura Greiss Hess, Sally J. Rogers, David Gosar, Kerrie Lemons-Chitwood, Randi Hagerman Nov 2009

Imitation In Fragile X Syndrome: Implications For Autism, Marta Macedoni-Luksic, Laura Greiss Hess, Sally J. Rogers, David Gosar, Kerrie Lemons-Chitwood, Randi Hagerman

Occupational Therapy | Faculty Scholarship

To address the specific impairment of imitation in autism, the imitation abilities of 22 children with fragile X syndrome (FXS) with and without autism were compared. Based on previous research, we predicted that children with FXS and autism would have significantly more difficulty with non-meaningful imitation tasks. After controlling for full-scale IQ and age, the groups did not differ in their overall imitation accuracy scores, but analysis of error patterns revealed that children with FXS and autism made more groping errors and additional movements than the comparison group. These error patterns are consistent with the hypothesis that an action production …

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Imitation In Fragile X Syndrome: Implications For Autism, Marta Macedoni-Luksic, Laura Greiss Hess, Sally J. Rogers, David Gosar, Kerrie Lemons-Chitwood, Randi Hagerman Oct 2009

Imitation In Fragile X Syndrome: Implications For Autism, Marta Macedoni-Luksic, Laura Greiss Hess, Sally J. Rogers, David Gosar, Kerrie Lemons-Chitwood, Randi Hagerman

Laura Greiss Hess

To address the specific impairment of imitation in autism, the imitation abilities of 22 children with fragile X syndrome (FXS) with and without autism were compared. Based on previous research, we predicted that children with FXS and autism would have significantly more difficulty with non-meaningful imitation tasks. After controlling for full-scale IQ and age, the groups did not differ in their overall imitation accuracy scores, but analysis of error patterns revealed that children with FXS and autism made more groping errors and additional movements than the comparison group. These error patterns are consistent with the hypothesis that an action production …

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Assistive Technology Use By Persons With Fragile X Syndrome, Laura Greiss Hess, K. L. Chitwood, S. W. Harris, M. Borodyankaya, R. J. Hagerman, C. Bodine, M. Gurainick Feb 2009

Assistive Technology Use By Persons With Fragile X Syndrome, Laura Greiss Hess, K. L. Chitwood, S. W. Harris, M. Borodyankaya, R. J. Hagerman, C. Bodine, M. Gurainick

Laura Greiss Hess

OBJECTIVES. This preliminary study examined sensory processing and its relationship to occupational performance in children with fragile X syndrome (FXS) to guide research and evidence-based practice. 

METHOD. Fifteen school-aged boys with full-mutation FXS were assessed with three occupational performance measures (School Function Assessment, Vineland Adaptive Behavior Scales, play duration) and three sensory processing measures (Sensory Profile, Tactile Defensiveness and Discrimination Test–Revised, Sensory Approach–Avoidance Rating). Data were analyzed using partial correlation procedures. 

RESULTS. Several significant correlations were found, independent of effects of age and IQ. Avoidance of sensory experiences (internally controlled) was associated with lower levels of school participation, self-care, and …

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Speech And Occupational Therapy, Laura Greiss Hess, Kerrie Lemons Chitwood Dec 2008

Speech And Occupational Therapy, Laura Greiss Hess, Kerrie Lemons Chitwood

Laura Greiss Hess

No abstract available

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Assistive Technology And The Iep, Laura Greiss Hess, Kerrie Lemons Chitwood May 2007

Assistive Technology And The Iep, Laura Greiss Hess, Kerrie Lemons Chitwood

Laura Greiss Hess

The concept of Assistive Technology (AT) can be overwhelming for many families and Individualized Education Program (IEP) teams. The purpose of this article is to provide parents with useful information about AT and how to go about addressing it as part of their child’s IEP. We also want to demystify AT and remind everyone that it does not mean just a computer or other communication device. AT is in fact very broad, and there should be a systematic process in place to document its consideration and use as part of the IEP.

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Occupational Therapy And Speech Therapy: A Collaborative Approach To Intervention For Fxs, Laura Greiss Hess, Kerrie Lemons Chitwood Sep 2006

Occupational Therapy And Speech Therapy: A Collaborative Approach To Intervention For Fxs, Laura Greiss Hess, Kerrie Lemons Chitwood

Laura Greiss Hess

No abstract available

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Assistive Technology Applications And Intervention Strategies For Individuals With Fxs, Laura Greiss Hess, Kerrie Lemons Chitwood, Susan Harris Jun 2006

Assistive Technology Applications And Intervention Strategies For Individuals With Fxs, Laura Greiss Hess, Kerrie Lemons Chitwood, Susan Harris

Laura Greiss Hess

No abstract available

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Sensory Processing Correlates Of Occupational Performance In Children With Fragile X Syndrome: Preliminary Findings, Grace T. Baranek, Yuki H. Chin, Laura Greiss Hess, Jann G. Yankee, Deborah D. Hatton, Stephen R. Hooper Aug 2002

Sensory Processing Correlates Of Occupational Performance In Children With Fragile X Syndrome: Preliminary Findings, Grace T. Baranek, Yuki H. Chin, Laura Greiss Hess, Jann G. Yankee, Deborah D. Hatton, Stephen R. Hooper

Laura Greiss Hess

OBJECTIVES. This preliminary study examined sensory processing and its relationship to occupational performance in children with fragile X syndrome (FXS) to guide research and evidence-based practice.

METHOD. Fifteen school-aged boys with full-mutation FXS were assessed with three occupational performance measures (School Function Assessment, Vineland Adaptive Behavior Scales, play duration) and three sensory processing measures (Sensory Profile, Tactile Defensiveness and Discrimination Test–Revised, Sensory Approach–Avoidance Rating). Data were analyzed using partial correlation procedures.

RESULTS. Several significant correlations were found, independent of effects of age and IQ. Avoidance of sensory experiences (internally controlled) was associated with lower levels of school participation, self-care, and …

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