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High Salt Intake Augments Excitability Of Pvn Neurons In Rats: Role Of The Endoplasmic Reticulum Ca2+ Store, Robert A. Larsen, Andrew D. Chapp, Le Gui, Michael J. Huber, Zixi Jack Cheng, Zhiying Shan, Qing-Hui Chen

Department of Kinesiology and Integrative Physiology Publications

High salt (HS) intake sensitizes central autonomic circuitry leading to sympathoexcitation. However, its underlying mechanisms are not fully understood. We hypothesized that inhibition of PVN endoplasmic reticulum (ER) Ca²⁺ store function would augment PVN neuronal excitability and sympathetic nerve activity (SNA). We further hypothesized that a 2% (NaCl) HS diet for 5 weeks would reduce ER Ca²⁺ store function and increase excitability of PVN neurons with axon projections to the rostral ventrolateral medulla (PVN-RVLM) identified by retrograde label. PVN microinjection of the ER Ca²⁺ ATPase inhibitor thapsigargin (TG) increased SNA and mean arterial pressure (MAP) in a …