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Full-Text Articles in Environmental Public Health
Using Physiologically-Based Pharmacokinetic Models To Incorporate Chemical And Non-Chemical Stressors Into Cumulative Risk Assessment: A Case Study Of Pesticide Exposures, Susan C. Wason, Thomas J. Smith, Melissa J. Perry, Jonathan I. Levy
Using Physiologically-Based Pharmacokinetic Models To Incorporate Chemical And Non-Chemical Stressors Into Cumulative Risk Assessment: A Case Study Of Pesticide Exposures, Susan C. Wason, Thomas J. Smith, Melissa J. Perry, Jonathan I. Levy
Environmental and Occupational Health Faculty Publications
Cumulative risk assessment has been proposed as an approach to evaluate the health risks associated with simultaneous exposure to multiple chemical and non-chemical stressors. Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can allow for the inclusion and evaluation of multiple stressors, including non-chemical stressors, but studies have not leveraged PBPK/PD models to jointly consider these disparate exposures in a cumulative risk context. In this study, we focused on exposures to organophosphate (OP) pesticides for children in urban low-income environments, where these children would be simultaneously exposed to other pesticides (including pyrethroids) and non-chemical stressors that may modify the effects of these exposures …