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Full-Text Articles in Public Health
Characterization Of The Impact Of Prenatal Cigarette Smoke Exposure On Age- And Sex-Specific Sirt1-Mediated Hepatic Molecular Phenotype In C57bl/6 Mice., Kendall S. Stocke
Characterization Of The Impact Of Prenatal Cigarette Smoke Exposure On Age- And Sex-Specific Sirt1-Mediated Hepatic Molecular Phenotype In C57bl/6 Mice., Kendall S. Stocke
Electronic Theses and Dissertations
In the U.S., 7.2% of women still report having smoked at some point during pregnancy despite known risks to fetal health. Prenatal cigarette smoke exposure (CSE) in children puts them at risk for low birth weight, premature birth, and other adverse impacts on developmental and postnatal health. Children subjected to prenatal CSE have a higher risk of adulthood metabolic disease predicted by the Barker Hypothesis. The hepatic molecular phenotype associated with this risk is unknown. This dissertation characterizes the prenatal CSE-induced hepatic molecular phenotype during three key life stages. We used a murine model of prenatal CSE utilizing a Teague …
Body Mass Index Trajectories: The Effect Of Fetal Size And Early Life Modifiable Factors, Mathew Roy
Body Mass Index Trajectories: The Effect Of Fetal Size And Early Life Modifiable Factors, Mathew Roy
Electronic Thesis and Dissertation Repository
Background: This study examined the relationship between small for gestational age (SGA) status at birth, a measure of fetal growth restriction, and childhood body mass index trajectories (BMI) using data from the National Longitudinal Survey of Children and Youth. Analytic Method: Using latent growth curve modeling, the growth trajectories of a cohort of small and appropriate for gestational age singletons were modeled from 2-10 years (N=1,273 at baseline). Results: SGA status had no effect on the growth trajectories of children after adjusting for prenatal and early life sociodemographic and maternal variables, and also early life modifiable factors. Moreover, the modifiable …