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The Progesterone Receptor Val660→Leu Polymorphism And Breast Cancer Risk, Immaculata De Vivo, Susan E. Hankinson, Graham A. Colditz, David J. Hunter
The Progesterone Receptor Val660→Leu Polymorphism And Breast Cancer Risk, Immaculata De Vivo, Susan E. Hankinson, Graham A. Colditz, David J. Hunter
Susan E. Hankinson
Background Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer. It has been reported that the PROGINS allele, which is in complete linkage disequilibrium with a missense substitution in exon 4 (G/T, valine→leucine, at codon 660), is associated with a decreased risk for breast cancer. Methods Using a nested case-control study design within the Nurses' Health Study cohort, …