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Full-Text Articles in Public Health
Premenopausal Endogenous Steroid Hormones And Breast Cancer Risk: Results From The Nurses’ Health Study Ii, Renée T. Fortner, A. Heather Eliassen, Donna Spiegelman, Walter C. Willett, Robert L. Barbieri, Susan E. Hankinson
Premenopausal Endogenous Steroid Hormones And Breast Cancer Risk: Results From The Nurses’ Health Study Ii, Renée T. Fortner, A. Heather Eliassen, Donna Spiegelman, Walter C. Willett, Robert L. Barbieri, Susan E. Hankinson
Susan E. Hankinson
Introduction: Prior research supports an association between endogenous sex steroids and breast cancer among postmenopausal women; the association is less clear among premenopausal women. Methods: We evaluated the associations between estrogens, androgens, progesterone and sex hormone binding globulin (SHBG) and breast cancer in a nested case-control study in the Nurses’ Health Study II. Between 1996 and 1999, 29,611 participants provided blood samples; 18,521 provided samples timed in early follicular and mid-luteal phases of the menstrual cycle. A total of 634 women, premenopausal at blood collection, developed breast cancer between 1999 and 2009 and were matched to 1,264 controls (514 cases …
Genetic Variability In Igf-1 And Igfbp-3 And Body Size In Early Life, Elizabeth Poole, Shelley Tworoger, Susan Hankinson, Heather Baer
Genetic Variability In Igf-1 And Igfbp-3 And Body Size In Early Life, Elizabeth Poole, Shelley Tworoger, Susan Hankinson, Heather Baer
Susan E. Hankinson
Background Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size. Methods We examined whether htSNPs in IGF-1 and the IGFBP-1/IGFBP-3 gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age …
Reproductive Aging-Associated Common Genetic Variants And The Risk Of Breast Cancer, Chunyan He, Daniel I. Chasman, Jill Dreyfus, Shih-Jen Hwang, Rikje Ruiter, Serena Sanna, Julie E. Buring, Lindsay Fernández-Rhodes, Nora Franceschini, Susan E. Hankinson, Albert Hofman, Kathryn L. Lunetta, Giuseppe Palmieri, Eleonora Porcu, Fernando Rivadeneira, Lynda M. Rose, Greta L. Splansky, Lisette Stolk, André G. Uitterlinden, Stephen J. Chanock, Laura Crisponi, Ellen W. Demerath, Joanne M. Murabito, Paul M. Ridker, Bruno H. Stricker, David J/ Hunter
Reproductive Aging-Associated Common Genetic Variants And The Risk Of Breast Cancer, Chunyan He, Daniel I. Chasman, Jill Dreyfus, Shih-Jen Hwang, Rikje Ruiter, Serena Sanna, Julie E. Buring, Lindsay Fernández-Rhodes, Nora Franceschini, Susan E. Hankinson, Albert Hofman, Kathryn L. Lunetta, Giuseppe Palmieri, Eleonora Porcu, Fernando Rivadeneira, Lynda M. Rose, Greta L. Splansky, Lisette Stolk, André G. Uitterlinden, Stephen J. Chanock, Laura Crisponi, Ellen W. Demerath, Joanne M. Murabito, Paul M. Ridker, Bruno H. Stricker, David J/ Hunter
Susan E. Hankinson
Introduction A younger age at menarche and an older age at menopause are well established risk factors for breast cancer. Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown. Methods In this study, we investigated 19 and 17 newly identified single nucleotide polymorphisms (SNPs) from the ReproGen Consortium that have been associated with age at menarche and age at natural menopause, respectively, and assessed their associations with breast cancer risk in 6 population-based studies among up to 3,683 breast cancer cases and …
Insulin-Like Growth Factor-1, Insulin-Like Growth Factor Binding Protein-3 And Lobule Type In The Nurses' Health Study Ii, Megan S. Rice, Rulla M. Tamimi, James L. Connolly, Laura C. Collins, Dejun Shen, Michael N.. Pollak, Bernard Rosner, Susan E. Hankinson, Shelley S. Tworoger
Insulin-Like Growth Factor-1, Insulin-Like Growth Factor Binding Protein-3 And Lobule Type In The Nurses' Health Study Ii, Megan S. Rice, Rulla M. Tamimi, James L. Connolly, Laura C. Collins, Dejun Shen, Michael N.. Pollak, Bernard Rosner, Susan E. Hankinson, Shelley S. Tworoger
Susan E. Hankinson
Introduction Previous research in the Nurses' Health Study (NHS) and the NHSII observed that, among women diagnosed with benign breast disease (BBD), those with predominant type 1/no type 3 lobules (a marker of complete involution) versus other lobule types were at lower risk of subsequent breast cancer. Studies in animal models suggest that insulin-like growth factor-1 (IGF-1) may inhibit involution of lobules in the breast; however, this has not been studied in humans. Methods We conducted a cross-sectional study among 472 women in the NHSII who were diagnosed with biopsy-confirmed proliferative BBD between 1991 and 2002 and provided blood samples …
The Combined Influence Of Multiple Sex And Growth Hormones On Risk Of Postmenopausal Breast Cancer: A Nested Case-Control Study, Shelley Tworoger, Bernard Rosner, Walter Willett, Susan Hankinson
The Combined Influence Of Multiple Sex And Growth Hormones On Risk Of Postmenopausal Breast Cancer: A Nested Case-Control Study, Shelley Tworoger, Bernard Rosner, Walter Willett, Susan Hankinson
Susan E. Hankinson
Introduction Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously. Methods We considered the roles of estrone, estradiol, estrone sulfate, testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA sulfate and prolactin and, secondarily, insulin-like growth factor 1 (IGF-1) and c-peptide in postmenopausal breast cancer risk among 265 cases and 541 controls in the prospective Nurses' Health Study. We created several hormone scores, including ranking women by the number of hormones above the age- and batch-adjusted geometric mean and weighting hormone values by their individual associations with breast cancer risk. …
Nondense Mammographic Area And Risk Of Breast Cancer, Andreas Pettersson, Susan E. Hankinson, Walter C. Willett, Pagona Lagiou, Dimitrios Trichopoulos, Rulla M. Tamimi
Nondense Mammographic Area And Risk Of Breast Cancer, Andreas Pettersson, Susan E. Hankinson, Walter C. Willett, Pagona Lagiou, Dimitrios Trichopoulos, Rulla M. Tamimi
Susan E. Hankinson
Introduction The mechanisms underlying the strong association between percentage dense area on a mammogram and the risk of breast cancer are unknown. We investigated separately the absolute dense area and the absolute nondense area on mammograms in relation to breast cancer risk. Methods We conducted a nested case-control study on prediagnostic mammographic density measurements and risk of breast cancer in the Nurses' Health Study and the Nurses' Health Study II. Premenopausal mammograms were available from 464 cases and 998 controls, and postmenopausal mammograms were available from 960 cases and 1,662 controls. We used a computer-assisted thresholding technique to measure mammographic …
Plasma 25-Hydroxyvitamin D And Risk Of Breast Cancer In The Nurses' Health Study Ii, A. Heather Eliassen, Donna Spiegelman, Bruce W. Hollis, Ronald L. Horst, Walter C. Willett, Susan E. Hankinson
Plasma 25-Hydroxyvitamin D And Risk Of Breast Cancer In The Nurses' Health Study Ii, A. Heather Eliassen, Donna Spiegelman, Bruce W. Hollis, Ronald L. Horst, Walter C. Willett, Susan E. Hankinson
Susan E. Hankinson
Introduction Experimental evidence indicates vitamin D may play an important role in breast cancer etiology but epidemiologic evidence to date is inconsistent. Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status. Methods We conducted a prospective nested case-control study within the Nurses' Health Study II (NHSII). Plasma samples collected in 1996 to 1999 were assayed for 25(OH)D in 613 cases, diagnosed after blood collection and before 1 June 2007, and in 1,218 matched controls. Multivariate relative risks (RR) and 95% confidence intervals (CI) were …
Risk Factors For Ductal And Lobular Breast Cancer: Results From The Nurses' Health Study, Joanne Kotsopoulos, Wendy Chen, Margaret Gates, Shelley Tworoger, Susan Hankinson, Bernard Rosner
Risk Factors For Ductal And Lobular Breast Cancer: Results From The Nurses' Health Study, Joanne Kotsopoulos, Wendy Chen, Margaret Gates, Shelley Tworoger, Susan Hankinson, Bernard Rosner
Susan E. Hankinson
Introduction Ductal and lobular carcinomas are the two most common types of invasive breast cancer. Whether well-established risk factors are differentially associated with risk on the basis of histologic subtype is not clear. We prospectively investigated the association between a number of hormonal and nonhormonal exposures and risk defined by histologic subtype among 4,655 ductal and 659 lobular cases of postmenopausal breast cancer from the Nurses' Health Study. Methods Multivariate Cox proportional hazards regression stratified by histologic subtype and time period was used to examine the association between risk factors and the incidence of ductal and lobular subtypes. For each …
Genetic Polymorphisms Of The Gnrh1 And Gnrhr Genes And Risk Of Breast Cancer In The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), Federico Canzian, Rudolf Kaaks, David G. Cox, Katherine D. Henderson, Brian E. Henderson, Christine Berg, Sheila Bingham, Heiner Boeing, Julie Buring, Eugenia E. Calle, Stephen Chanock, Francoise Clavel-Chapelon, Laure Dossus, Heather S. Feigelson, Christopher A. Haiman, Susan E. Hankinson
Genetic Polymorphisms Of The Gnrh1 And Gnrhr Genes And Risk Of Breast Cancer In The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), Federico Canzian, Rudolf Kaaks, David G. Cox, Katherine D. Henderson, Brian E. Henderson, Christine Berg, Sheila Bingham, Heiner Boeing, Julie Buring, Eugenia E. Calle, Stephen Chanock, Francoise Clavel-Chapelon, Laure Dossus, Heather S. Feigelson, Christopher A. Haiman, Susan E. Hankinson
Susan E. Hankinson
Background Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence breast cancer risk by modulating production of ovarian steroid hormones. We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3). Methods We sequenced exons of GNRH1 and GNRHR in 95 invasive breast cancer cases. Resulting single nucleotide polymorphisms (SNPs) were genotyped and used to identify haplotype-tagging SNPs …
A Prospective Study Of Androgen Levels, Hormone-Related Genes And Risk Of Rheumatoid Arthritis, Elizabeth W. Karlson, Lori B. Chibnik, Monica Mcgrath, Shun-Chiao Chang, Brendan T. Keenan, Karen H. Costenbader, Patricia A. Fraser, Shelley Tworoger, Susan E. Hankinson, I-Min Le, Julie Buring, Immaculata De Vivo
A Prospective Study Of Androgen Levels, Hormone-Related Genes And Risk Of Rheumatoid Arthritis, Elizabeth W. Karlson, Lori B. Chibnik, Monica Mcgrath, Shun-Chiao Chang, Brendan T. Keenan, Karen H. Costenbader, Patricia A. Fraser, Shelley Tworoger, Susan E. Hankinson, I-Min Le, Julie Buring, Immaculata De Vivo
Susan E. Hankinson
Introduction Rheumatoid arthritis (RA) is more common in females than males and sex steroid hormones may in part explain this difference. We conducted a case–control study nested within two prospective studies to determine the associations between plasma steroid hormones measured prior to RA onset and polymorphisms in the androgen receptor (AR), estrogen receptor 2 (ESR2), aromatase (CYP19) and progesterone receptor (PGR) genes and RA risk. Methods We genotyped AR, ESR2, CYP19, PGR SNPs and the AR CAG repeat in RA case–control studies nested within the Nurses' Health Study (NHS), NHS II (449 RA cases, 449 controls) and the Women's Health …
Breast Cancer Susceptibility Loci And Mammographic Density, Rulla M. Tamimi, David Cox, Peter Kraft, Graham A. Colditz, Susan E. Hankinson, David J. Hunter
Breast Cancer Susceptibility Loci And Mammographic Density, Rulla M. Tamimi, David Cox, Peter Kraft, Graham A. Colditz, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Introduction Recently, the Breast Cancer Association Consortium (BCAC) conducted a multi-stage genome-wide association study and identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Given the high degree of heritability of mammographic density and its strong association with breast cancer, it was hypothesised that breast cancer susceptibility loci may also be associated with breast density and provide insight into the biology of breast density and how it influences breast cancer risk. Methods We conducted an analysis in the Nurses' Health Study (n = 1121) to assess the relation between 11 breast cancer susceptibility loci and mammographic density. At …
Risk Prediction Models With Incomplete Data With Application To Prediction Of Estrogen Receptor-Positive Breast Cancer: Prospective Data From The Nurses' Health Study, Bernard Rosner, Graham A. Colditz, J. Dirk Iglehart, Susan E. Hankinson
Risk Prediction Models With Incomplete Data With Application To Prediction Of Estrogen Receptor-Positive Breast Cancer: Prospective Data From The Nurses' Health Study, Bernard Rosner, Graham A. Colditz, J. Dirk Iglehart, Susan E. Hankinson
Susan E. Hankinson
Introduction A number of breast cancer risk prediction models have been developed to provide insight into a woman's individual breast cancer risk. Although circulating levels of estradiol in postmenopausal women predict subsequent breast cancer risk, whether the addition of estradiol levels adds significantly to a model's predictive power has not previously been evaluated. Methods Using linear regression, the authors developed an imputed estradiol score using measured estradiol levels (the outcome) and both case status and risk factor data (for example, body mass index) from a nested case-control study conducted within a large prospective cohort study and used multiple imputation methods …
Biological Variability Dominates And Influences Analytical Variance In Hplc-Ecd Studies Of The Human Plasma Metabolome, Yevgeniya I. Shurubor, Wayne R. Matson, Walter C. Willett, Susan E. Hankinson, Bruce S. Kristal
Biological Variability Dominates And Influences Analytical Variance In Hplc-Ecd Studies Of The Human Plasma Metabolome, Yevgeniya I. Shurubor, Wayne R. Matson, Walter C. Willett, Susan E. Hankinson, Bruce S. Kristal
Susan E. Hankinson
Background Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations coupled with coulometric array detection that can accurately identify ad libitum fed and caloric-restricted rats. These profiles are being adapted for human epidemiology studies, given the importance of energy balance in human disease. Methods Human plasma samples were biochemically analyzed using HPLC separations coupled with coulometric electrode array detection. Results We identified these markers/metabolites in human plasma, and then used them to determine which human samples represent blinded duplicates with 100% accuracy (N = 30 of 30). …
Tgfb1 And Tgfbr1 Polymorphisms And Breast Cancer Risk In The Nurses' Health Study, David G. Cox, Kathryn Penney, Qun Guo, Susan E. Hankinson, David J. Hunter
Tgfb1 And Tgfbr1 Polymorphisms And Breast Cancer Risk In The Nurses' Health Study, David G. Cox, Kathryn Penney, Qun Guo, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Background Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results. Methods We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. Results No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse …
Common Genetic Variation In Igf1, Igfbp-1, And Igfbp-3 In Relation To Mammographic Density: A Cross-Sectional Study, Rulla M. Tamimi, David G. Cox, Peter Kraft, Michael N. Pollak, Christopher A. Haiman, Iona Cheng, Matthew L. Freedman, Susan E. Hankinson, David J. Hunter, Graham A. V. Colditz
Common Genetic Variation In Igf1, Igfbp-1, And Igfbp-3 In Relation To Mammographic Density: A Cross-Sectional Study, Rulla M. Tamimi, David G. Cox, Peter Kraft, Michael N. Pollak, Christopher A. Haiman, Iona Cheng, Matthew L. Freedman, Susan E. Hankinson, David J. Hunter, Graham A. V. Colditz
Susan E. Hankinson
Introduction Mammographic density is one of the strongest risk factors for breast cancer and is believed to represent epithelial and stromal proliferation. Because of the high heritability of breast density, and the role of the insulin-like growth factor (IGF) pathway in cellular proliferation and breast development, we examined the association between common genetic variation in this pathway and mammographic density. Methods We conducted a cross-sectional analysis among controls (n = 1,121) who were between the ages of 42 and 78 years at mammography, from a breast cancer case-control study nested within the Nurses' Health Study cohort. At the time of …
A Polymorphism In The 3' Untranslated Region Of The Gene Encoding Prostaglandin Endoperoxide Synthase 2 Is Not Associated With An Increase In Breast Cancer Risk: A Nested Case-Control Study, David G. Cox, Julie Buring, Susan E. Hankinson, David J. Hunter
A Polymorphism In The 3' Untranslated Region Of The Gene Encoding Prostaglandin Endoperoxide Synthase 2 Is Not Associated With An Increase In Breast Cancer Risk: A Nested Case-Control Study, David G. Cox, Julie Buring, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Introduction Prostaglandins are integral components in the cellular response to inflammation, promoting cellular proliferation and angiogenesis. The enzyme responsible for the conversion of arachidonic acid to prostaglandins in response to inflammation is prostaglandin endoperoxide synthase 2/cyclo-oxygenase 2 (PTGS2/COX2). Polymorphisms in the PTGS2 gene have been associated with various diseases, including inflammatory bowel disease and cancer of the lung, colorectum, and breast. Methods We genotyped the five most common polymorphisms (rs20417, rs5277, rs20432, rs5275, and rs4648298) in the Nurses' Health Study (1,270 cases, 1,762 controls) to test the hypothesis that polymorphisms in PTGS2 are associated with breast cancer risk, using logistic …
A Comprehensive Analysis Of The Androgen Receptor Gene And Risk Of Breast Cancer: Results From The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), David G. Cox, Hélène Blanché, Celeste L. Pearce, Eugenia E. Calle, Graham A. Colditz, Malcolm C. Pike, Demetrius Albanes, Naomi E. Allen, Pilar Amiano, Goran Berglund, Heiner Boeing, Julie Buring, Noel Burtt, Federico Canzian, Stephen Chanock, Françoise Clavel-Chapelon, Heather S. Feigelson, Matthew Freedman, Christopher A. Haiman, Susan E. Hankinson, Brian E. Henderson, Robert Hoover, David J. Hunter, Rudolf Kaaks, Laurence Kolonel, Peter Kraft, Loic Lemarchand, Eiliv Lund, Domenico Palli, Petra H.M. Peeters, Elio Riboli, Daniel O. Stram, Michael Thun, Anne Tjonneland, Dimitrios Trichopoulos, Meredith Yeager
A Comprehensive Analysis Of The Androgen Receptor Gene And Risk Of Breast Cancer: Results From The National Cancer Institute Breast And Prostate Cancer Cohort Consortium (Bpc3), David G. Cox, Hélène Blanché, Celeste L. Pearce, Eugenia E. Calle, Graham A. Colditz, Malcolm C. Pike, Demetrius Albanes, Naomi E. Allen, Pilar Amiano, Goran Berglund, Heiner Boeing, Julie Buring, Noel Burtt, Federico Canzian, Stephen Chanock, Françoise Clavel-Chapelon, Heather S. Feigelson, Matthew Freedman, Christopher A. Haiman, Susan E. Hankinson, Brian E. Henderson, Robert Hoover, David J. Hunter, Rudolf Kaaks, Laurence Kolonel, Peter Kraft, Loic Lemarchand, Eiliv Lund, Domenico Palli, Petra H.M. Peeters, Elio Riboli, Daniel O. Stram, Michael Thun, Anne Tjonneland, Dimitrios Trichopoulos, Meredith Yeager
Susan E. Hankinson
Introduction: Androgens have been hypothesised to influence risk of breast cancer through several possible mechanisms, including their conversion to estradiol or their binding to the oestrogen receptor and/or androgen receptor (AR) in the breast. Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Methods: The underlying genetic variation was determined by first sequencing the coding regions of the AR gene in a panel of 95 advanced breast cancer cases. Second, …
Haplotype Analysis Of Common Variants In The Brca1 Gene And Risk Of Sporadic Breast Cancer, David G. Cox, Peter Kraft, Susan E. Hankinson, David J. Hunter
Haplotype Analysis Of Common Variants In The Brca1 Gene And Risk Of Sporadic Breast Cancer, David G. Cox, Peter Kraft, Susan E. Hankinson, David J. Hunter
Susan E. Hankinson
Introduction Truncation mutations in the BRCA1 gene cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population and account for little of the overall incidence of sporadic breast cancer. Method We used whole-gene resequencing data to select haplotype tagging single nucleotide polymorphisms, and examined the association between common haplotypes of BRCA1 and breast cancer in a nested case-control study in the Nurses' Health Study (1323 cases and 1910 controls). Results One haplotype was associated with a slight increase in risk (odds ratio 1.18, 95% confidence interval 1.02–1.37). A significant interaction (P = …
The Progesterone Receptor Val660→Leu Polymorphism And Breast Cancer Risk, Immaculata De Vivo, Susan E. Hankinson, Graham A. Colditz, David J. Hunter
The Progesterone Receptor Val660→Leu Polymorphism And Breast Cancer Risk, Immaculata De Vivo, Susan E. Hankinson, Graham A. Colditz, David J. Hunter
Susan E. Hankinson
Background Recent evidence suggests a role for progesterone in breast cancer development and tumorigenesis. Progesterone exerts its effect on target cells by interacting with its receptor; thus, genetic variations, which might cause alterations in the biological function in the progesterone receptor (PGR), can potentially contribute to an individual's susceptibility to breast cancer. It has been reported that the PROGINS allele, which is in complete linkage disequilibrium with a missense substitution in exon 4 (G/T, valine→leucine, at codon 660), is associated with a decreased risk for breast cancer. Methods Using a nested case-control study design within the Nurses' Health Study cohort, …
Towards An Integrated Model For Breast Cancer Etiology: The Lifelong Interplay Of Genes, Lifestyle, And Hormones, Susan E. Hankinson, Graham A. Colditz, Walter C. Willett
Towards An Integrated Model For Breast Cancer Etiology: The Lifelong Interplay Of Genes, Lifestyle, And Hormones, Susan E. Hankinson, Graham A. Colditz, Walter C. Willett
Susan E. Hankinson
While the association of a number of risk factors, such as family history and reproductive patterns, with breast cancer has been well established for many years, work in the past 10–15 years also has added substantially to our understanding of disease etiology. Contributions of particular note include the delineation of the role of endogenous and exogenous estrogens to breast cancer risk, and the discovery and quantification of risk associated with several gene mutations (e.g. BRCA1). Although it is difficult to integrate all epidemiologic data into a single biologic model, it is clear that several important components or pathways exist. Early …
Common Ataxia Telangiectasia Mutated Haplotypes And Risk Of Breast Cancer: A Nested Case–Control Study, Rulla Tamimi, Susan Hankinson, Donna Spiegelman, Peter Kraft, Graham Colditz, David Hunter
Common Ataxia Telangiectasia Mutated Haplotypes And Risk Of Breast Cancer: A Nested Case–Control Study, Rulla Tamimi, Susan Hankinson, Donna Spiegelman, Peter Kraft, Graham Colditz, David Hunter
Susan E. Hankinson
Introduction The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast cancer compared with noncarriers of the mutations, although not all studies have confirmed this association. Haplotype analysis has been suggested as an efficient method for investigating the role of common variation in the ATM gene and breast cancer. Five biallelic haplotype tagging single nucleotide polymorphisms are estimated to capture 99% of …
Polymorphic Repeat In Aib1 Does Not Alter Breast Cancer Risk, Haiman Christopher, Susan Hankinson, Donna Spiegelman, Graham Colditz, Walter Willett, Frank Speizer, Myles Brown, David Hunter
Polymorphic Repeat In Aib1 Does Not Alter Breast Cancer Risk, Haiman Christopher, Susan Hankinson, Donna Spiegelman, Graham Colditz, Walter Willett, Frank Speizer, Myles Brown, David Hunter
Susan E. Hankinson
We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.