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Full-Text Articles in Mental Disorders
Septohippocampal Gabaergic Neurons Mediate The Altered Behaviors Induced By N-Methyl-D-Aspartate Receptor Antagonists., Jingyi Ma, Siew Kian Tai, L Stan Leung
Septohippocampal Gabaergic Neurons Mediate The Altered Behaviors Induced By N-Methyl-D-Aspartate Receptor Antagonists., Jingyi Ma, Siew Kian Tai, L Stan Leung
Physiology and Pharmacology Publications
We hypothesize that selective lesion of the septohippocampal GABAergic neurons suppresses the altered behaviors induced by an N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine or MK-801. In addition, we hypothesize that septohippocampal GABAergic neurons generate an atropine-resistant theta rhythm that coexists with an atropine-sensitive theta rhythm in the hippocampus. Infusion of orexin-saporin (ore-SAP) into the medial septal area decreased parvalbumin-immunoreactive (GABAergic) neurons by ~80%, without significantly affecting choline-acetyltransferase-immunoreactive (cholinergic) neurons. The theta rhythm during walking, or the immobility-associated theta induced by pilocarpine, was not different between ore-SAP and sham-lesion rats. Walking theta was, however, more disrupted by atropine sulfate in ore-SAP than …
Psychosis In Indigenous Populations Of Cape York And The Torres Strait, Ernest M. Hunter, Bruce D. Gynther, Carrick J. Anderson, Leigh-Ann L. Onnis, Jeffrey R. Nelson, Wayne Hall, Bernhard T. Baune, Aaron R. Groves
Psychosis In Indigenous Populations Of Cape York And The Torres Strait, Ernest M. Hunter, Bruce D. Gynther, Carrick J. Anderson, Leigh-Ann L. Onnis, Jeffrey R. Nelson, Wayne Hall, Bernhard T. Baune, Aaron R. Groves
Aboriginal Policy Research Consortium International (APRCi)
Objective: To describe and characterise treated psychotic disorders in the Indigenous populations of Cape York and the Torres Strait.
Design: Cross-sectional analysis of patients with a psychotic disorder identified by treating psychiatrists.
Setting and participants: Indigenous patients aged 15 years in Cape York and Torres Strait communities receiving treatment for a psychotic disorder over 3 months in 2010.
Main outcome measures: Prevalence of psychosis diagnoses, intellectual disability, and substance use comorbidities.
Results: 171 patients were included. The prevalence rate in this population was 1.68%, higher for males (2.60%) than females (0.89%), and twice as high in the Aboriginal (2.05%) …