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Behavior and Behavior Mechanisms Commons™
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Full-Text Articles in Behavior and Behavior Mechanisms
Dietary Probiotic Supplement Attenuates Methamphetamine-Induced Conditioned Place Preference In Female Sprague-Dawley Rats, Kristen Powell
Dietary Probiotic Supplement Attenuates Methamphetamine-Induced Conditioned Place Preference In Female Sprague-Dawley Rats, Kristen Powell
Masters Theses
Substance use disorders (SUD) represent a global public health crisis with limited effective treatment options. Recent findings implicate the gut microbiome and gut/brain axis in the pathophysiology of SUDs. Several preclinical studies have established that psychostimulants alter gut microbiome composition, but no published studies have assessed behavioral effects of dietary probiotic supplements on drug-induced behavioral changes. This study utilized rodent conditioned place preference (CPP) as a behavioral index of conditioned drug reward to determine if a dietary probiotic supplement alters the behavioral effects of (+)-methamphetamine (METH). Fifty-four adult female Sprague-Dawley rats were randomly assigned to receive either a standard rodent …
Effects Of Low Dose Mixtures Of 3,4-Methylenedioxypyrovalerone And Cocaine On Locomotor Activity And Brain Monoamine Content In Sprague-Dawley Rats, Robert J. Kohler
Effects Of Low Dose Mixtures Of 3,4-Methylenedioxypyrovalerone And Cocaine On Locomotor Activity And Brain Monoamine Content In Sprague-Dawley Rats, Robert J. Kohler
Masters Theses
Synthetic cathinones, known as “bath salts” on the illicit drug market, pose a significant and growing public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of the illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one of four treatments: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV + 5 mg/kg cocaine, or saline. Locomotor activity was assessed for one hour immediately before and one hour …
The Acute Effects Of Cocaine In Pigeons Performing Under A Progressive-Ratio Schedule, Claudia Ann Jones
The Acute Effects Of Cocaine In Pigeons Performing Under A Progressive-Ratio Schedule, Claudia Ann Jones
Masters Theses
Although the progressive-ratio (PR) schedule has been used frequently to quantify the reinforcing effectiveness of self-administered drugs, it has seldom been used to examine the effects of drugs on food-maintained behavior and has never been used to evaluate the effects of cocaine on such behavior. In the present study, the effects of acute administrations of cocaine were evaluated in pigeons responding under a PR schedule of food delivery. Overall, cocaine produced a dose-dependent effect on food-maintained behavior. In general, acute administrations of cocaine at 0.56 to 3.2 mg/kg increased breaking points, whereas doses above 5.6 mg/kg decreased breaking points. Low …