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Articles 1 - 30 of 51
Full-Text Articles in Psychiatry and Psychology
Binge Drinking In College: A Phenomenological Study, Kristin Andrews
Binge Drinking In College: A Phenomenological Study, Kristin Andrews
Murray State Theses and Dissertations
This phenomenological research study examined the personal experiences, habits, and perceptions of post-secondary students who binge drink. This study was guided by 3 research questions as well as pre-existing research into collegiate binge drinking. The experiences shared by participants showed that despite serious negative outcomes, students binge drink because they feel negatives are far outweighed by the positive social interactions and fun drinking creates. While all of the participants in this study are considered binge drinkers who abuse alcohol, none of the participants considered their drinking to be problematic. The participants shared their intent to stop their current drinking patters …
Higher Sexual Excitation Is Associated With An Increase In Sex-Linked Substance Use In Women With A History Of Unwanted Sexual Contact, Harper R. Jones, Tierney K. Lorenz
Higher Sexual Excitation Is Associated With An Increase In Sex-Linked Substance Use In Women With A History Of Unwanted Sexual Contact, Harper R. Jones, Tierney K. Lorenz
Center for Brain, Biology, and Behavior: Faculty and Staff Publications
Survivors of unwanted sexual contact have an increased likelihood of using substances in sexual situations, which puts them at heightened risk for intoxication-related harms. Separately, research has indicated that women may intentionally use substances in sexual situations to either enhance pleasure (i.e., increase sexual excitation) and/or reduce sexual anxiety or shame (i.e., reduce sexual inhibition), a phenomenon termed sex-linked substance use (SLSU). A predominant assumption in the literature is that women with unwanted sex histories are more likely to disengage during sex, suggesting greater inhibition-related SLSU; however, there is little prior research directly examining if women who have unwanted sex …
How To Survive College As An Acoa: The Effectiveness Of University Resources On Helping Acoas Socially And Psychologically Succeed During Their Academic Career, Kelly Buchan
Senior Theses
In 2019, 14.5 million people ages 12 and older had Alcohol Use Disorder (AUD), but only 10% received treatment (National Institute on Alcohol Abuse and Alcoholism [NIAAA], 2022). Parental drinking problems can directly affect children, or “Adult Children of Alcoholics.” Of the few studies targeting ACoAs, results show that ACoAs not only have higher risks of mental illness, but they also have lower GPAs and social health (Schroeder & Kelley, 2008). Thus, this study assessed the extent to which perceptions of the college drinking environment are related to higher depression rates in ACoAs, certain drinking motivations, and reluctance to use …
Associations Of Discrimination With Drinking Behavior In Multiracial College Students: Protective Role Of Racial Socialization, Fatima Dobani
Associations Of Discrimination With Drinking Behavior In Multiracial College Students: Protective Role Of Racial Socialization, Fatima Dobani
Theses - ALL
Despite the rapid growth of the Multiracial population in the United States, less is known about correlates of their health behaviors. Nascent findings demonstrate elevated rates of drinking behavior among Multiracial college students compared to their monoracial counterparts. Theoretical models posit that racial socialization by primary caregivers may change the magnitude of the relationship of discrimination with drinking behavior among Multiracial individuals. The role of racial socialization, however, has not been tested specifically among Multiracial college students. In this cross-sectional survey study, 193 undergraduate students (Mage = 20 years [SD = 1.33]; 30% male; 33% Greek affiliated) reporting lifetime alcohol …
Direct And Indirect Effects Of Alcohol Craving And Demand On Obsessive And Compulsive Drinking Characteristics: The Role Of Impulsivity, James V. Turner Iv
Direct And Indirect Effects Of Alcohol Craving And Demand On Obsessive And Compulsive Drinking Characteristics: The Role Of Impulsivity, James V. Turner Iv
Theses and Dissertations
This study’s goal was to test a novel model of obsessive-compulsive thoughts about drinking. Young adults completed tasks measuring potential drinking characteristics. Findings indicated demand was related to higher OCTD, a significant effect of CIC on OCTD via demand, and that the relationship was particularly strong for impulsive individuals.
A Measure Of Expectancies For Alcohol Analgesia: Preliminary Factor Analysis, Reliability, And Validity, Lisa Renee Larowe
A Measure Of Expectancies For Alcohol Analgesia: Preliminary Factor Analysis, Reliability, And Validity, Lisa Renee Larowe
Dissertations - ALL
Rates of alcohol consumption are substantially higher among persons with pain, and recent research has focused on elucidating bidirectional pain-alcohol effects. Expectancies for alcohol analgesia could influence the degree to which alcohol confers acute pain-relieving effects, and may amplify the propensity to respond to pain with drinking behavior. However, no validated measures of expectancies for alcohol analgesia are available. The goal of this project was to examine psychometric properties of a measure of Expectancies for Alcohol Analgesia (EAA) across two samples (current alcohol users with and without chronic pain). Study 1 included 200 moderate-to-heavy drinkers with no current acute/chronic pain …
Negative Urgency's Influence On State-Level, Emotion-Based Changes In Alcohol-Related Cognitions, Noah Wolkowicz
Negative Urgency's Influence On State-Level, Emotion-Based Changes In Alcohol-Related Cognitions, Noah Wolkowicz
Graduate Theses and Dissertations
This project expanded on the Acquired Preparedness Model of Risk (APMR) by examining how Negative Urgency (NU), the tendency to act rashly in negative emotional states, affects emotion-based changes in alcohol cognitions to produce risk for alcohol use. The APMR prioritizes the role of outcome expectancies as the means through which traits such as NU, convey alcohol use risk. However, this model treats these cognitions as static and often fails to assess their valence; further, alcohol-cognitions fluctuate in response to negative emotions and may become more salient during these states. Therefore, this study examined: 1) how NU impacts negative emotion-based, …
Why Can't Homeless Addicts Get Help Too, Rachael D. Causland
Why Can't Homeless Addicts Get Help Too, Rachael D. Causland
English Department: Research for Change - Wicked Problems in Our World
Homeless people today struggle more with addiction than people who have stability in their life. Whether it’s due to financial issues, or not having a support system, homeless people struggle to get the help they need for both their addiction and their homelessness. A high number of homeless people report to have started an addiction since being homeless, and they do so to stay alive, in turn people are continuing to stay homeless and many of these people are dying of overdoses or just staying stuck in the situation they are forced to deal with alone. There are some states …
The Influence Of Military Service Experiences On Current And Daily Drinking, Andrew S. London, Janet M. Wilmoth, William J. Oliver, Jessica A. Hausauer
The Influence Of Military Service Experiences On Current And Daily Drinking, Andrew S. London, Janet M. Wilmoth, William J. Oliver, Jessica A. Hausauer
Population Health Research Brief Series
Traumatic military service experience can lead to increased alcohol consumption among veterans, who may use alcohol as a form of self-medication. Veterans with a psychiatric disorder or traumatic brain injury are more likely than nonveterans to be daily drinkers. Non-combat and combat veterans without a PD or TBI are less likely than nonveterans to be daily drinkers.
Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt
Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt
Theses and Dissertations
Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …
Experiential Avoidance And Negative Affect As Predictors Of Daily Drinking, Jason B. Luoma, Benjamin G. Pierce, Michael E. Levin
Experiential Avoidance And Negative Affect As Predictors Of Daily Drinking, Jason B. Luoma, Benjamin G. Pierce, Michael E. Levin
Psychology Faculty Publications
People who drink alcohol to cope with negative affect tend to drink more and experience more frequent negative alcohol-related consequences. Experiential avoidance, the tendency to avoid, suppress, or otherwise attempt to control unwanted inner experiences, is a largely pathological process that may help account for how negative affect is linked to increased alcohol consumption. However, research to-date has typically used global, trait-like measures, which limit our understanding of the conditions under which experiential avoidance is problematic. The current study tested both between-person (trait) and within-person (daily) variation in experiential avoidance and negative affect as predictors of solitary and social drinking …
Social Anxiety Reduction In The Context Of Social Modeling Utilizing A Placebo Alcohol Beverage, Kyle K. Jackson
Social Anxiety Reduction In The Context Of Social Modeling Utilizing A Placebo Alcohol Beverage, Kyle K. Jackson
Graduate Theses and Dissertations
Alcohol misuse and elevated social anxiety are found to be highly comorbid, and being exposed to social models consuming alcohol can increase one’s consumption. Yet no research has thus far examined whether the internal experience of alcohol consumption (e.g., social anxiety reduction) can also be transmitted via social modeling. This bar-lab study examined the impact of social modeling behavioral cues of social anxiety on emerging adult drinkers. It was hypothesized that those exposed to a social model experiencing an apparent social anxiety reduction from drinking would themselves report lessened state social anxiety following a placebo drink, and that this effect …
How Does Alcohol Intoxication Impair Risk Detection Of Sexual Assault? Testing An Integration Of Alcohol Myopia And Social Information Processing Theories, Alexander James Melkonian
How Does Alcohol Intoxication Impair Risk Detection Of Sexual Assault? Testing An Integration Of Alcohol Myopia And Social Information Processing Theories, Alexander James Melkonian
Graduate Theses and Dissertations
Sexual assault among young adults is a highly prevalent public health concern. Alcohol is often implicated as a risk factor for sexual assault through its impairing effects on an individual’s ability to process and respond to social cues in the environment. The effect of alcohol myopia can result in greater focus of attention on salient environmental cues. The relationship between alcohol intoxication and resulting behavior may depend on what type of information is most salient. The current study examined the effects of alcohol on social information processing as it relates to sexual assault risk detection. Method: Participants were 48 young …
Evaluation Of A New Trauma-Related Drinking To Cope Measure: Latent Structure And Heritability, Sage E. Hawn, Steven H. Aggen, Danielle Dick, Ananda B. Amstadter Phd
Evaluation Of A New Trauma-Related Drinking To Cope Measure: Latent Structure And Heritability, Sage E. Hawn, Steven H. Aggen, Danielle Dick, Ananda B. Amstadter Phd
Graduate Research Posters
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur, share latent genetic risk, and are associated with many negative public health outcomes. Via a self-medication framework, trauma-related drinking to cope (TRD), an unexplored phenotype to date, may help explain why these two disorders co-occur, thus serving as an essential target for treatment and prevention efforts. This study sought to create a novel measure of TRD and to investigate its indirect influences on the association between PTSD and AUD, as well as its potential shared molecular genetic risk with PTSD in a genetically-informative study of college students. A sample …
What's In Your Cup? Increasing Transparency And Confidence In Alcohol Use Screening And Brief Intervention, Dylan C. Koundakjian
What's In Your Cup? Increasing Transparency And Confidence In Alcohol Use Screening And Brief Intervention, Dylan C. Koundakjian
Family Medicine Clerkship Student Projects
19% of Vermonters report drinking alcohol at levels which puts their health at risk, but many healthcare providers do not feel confident in addressing their patients' usage. This can stem from lack of experience with alcohol use, worries about stigma, and time constraints. However, data has shown that even 5-15 minute interventional conversations can significantly reduce a patient's risky drinking. This project aims to provide real-world, practical advice for having conversations around alcohol, and provides a conversion chart converting popular alcoholic beverages into standard drink equivalents.
Effects Of Multisensory Stop Signals On Sensitivity To Alcohol-Induced Disinhibition In Drinkers With Adhd, Alexandra R. D'Agostino
Effects Of Multisensory Stop Signals On Sensitivity To Alcohol-Induced Disinhibition In Drinkers With Adhd, Alexandra R. D'Agostino
Theses and Dissertations--Psychology
Multisensory environments facilitate behavioral functioning in humans. The redundant signal effect (RSE) refers to the observation that individuals respond more quickly to stimuli when information is presented as multisensory, redundant stimuli rather than as a single stimulus presented to either modality alone. Our studies show that the disinhibiting effects of alcohol are attenuated when stop signals are multisensory versus unisensory. The present study expanded on this research to test the degree to which multisensory stop signals could also attenuate the disinhibiting effects of alcohol in those with attention-deficit hyperactivity disorder (ADHD), a clinical population characterized by poor impulse control. The …
Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy E. Schoenberg, Catherine A. Martin, Richard Clayton
Pharmacy Staff Perspectives On Alcohol And Medication Interaction Prevention Among Older Rural Adults, Faika Zanjani, Hannah Allen, Rachel Vickers Smith, Demetra Antimisiaris, Nancy E. Schoenberg, Catherine A. Martin, Richard Clayton
Behavioral Science Faculty Publications
Older adults are at high risk for alcohol and medication interactions (AMI). Pharmacies have the potential to act as ideal locations for AMI education, as pharmacy staff play an important role in the community. This study examined the perspectives of pharmacy staff on AMI prevention programming messaging, potential barriers to and facilitators of older adult participation in such programming, and dissemination methods for AMI prevention information. Flyers, telephone calls, and site visits were used to recruit 31 pharmacy staff members who participated in semistructured interviews. A content analysis of interview transcriptions was conducted to identify major themes, categories, and subcategories. …
Effects Of Mild Traumatic Brain Injury On Ethanol Consumption And The Combined Effects On Neuroinflammation, Cognition, And Behavior In Mice, Jessica L. Hoffman
Effects Of Mild Traumatic Brain Injury On Ethanol Consumption And The Combined Effects On Neuroinflammation, Cognition, And Behavior In Mice, Jessica L. Hoffman
USF Tampa Graduate Theses and Dissertations
The relationship between alcohol consumption and traumatic brain injury (TBI) often focuses on alcohol consumption increasing the likelihood of incurring a TBI, rather than alcohol use outcomes after TBI. This focus is in part due to the large numbers of TBI patients visiting emergency rooms notable levels of alcohol in their blood. Additionally, increases in alcohol use disorders following TBI can be predicted by previous history of alcohol use. However, studies have also shown patients without a history of an alcohol use disorder can experience increases in problem drinking after single or multiple TBIs. Due to the diffuse impact of …
Principal Component Analysis Of Early Alcohol, Drug And Tobacco Use With Major Depressive Disorder In Us Adults, Kesheng Wang, Ying Liu, Youssoufou Ouedraogo, Nianyang Wang, Xin Xie, Chun Xu, Xingguang Luo
Principal Component Analysis Of Early Alcohol, Drug And Tobacco Use With Major Depressive Disorder In Us Adults, Kesheng Wang, Ying Liu, Youssoufou Ouedraogo, Nianyang Wang, Xin Xie, Chun Xu, Xingguang Luo
Health & Biomedical Sciences Faculty Publications and Presentations
Early alcohol, tobacco and drug use prior to 18 years old are comorbid and correlated. This study included 6239 adults with major depressive disorder (MDD) in the past year and 72,010 controls from the combined data of 2013 and 2014 National Survey on Drug Use and Health (NSDUH). To deal with multicollinearity existing among 17 variables related to early alcohol, tobacco and drug use prior to 18 years old, we used principal component analysis (PCA) to infer PC scores and then use weighted multiple logistic regression analyses to estimate the associations of potential factors and PC scores with MDD. The …
Attentional Bias To Alcohol In An In Vivo Setting, Ramey G. Monem
Attentional Bias To Alcohol In An In Vivo Setting, Ramey G. Monem
Theses and Dissertations--Psychology
The phenomenon of attentional bias to alcohol, where drinkers demonstrate a preference in allocating visual attention towards alcohol-related stimuli rather than neutral stimuli, is well-established. Studies detecting this phenomenon typically utilize computer-administered stimulus presentation tasks such as the visual dot probe task. Despite their frequency of use, these tasks do not represent the ways in which individuals typically encounter alcohol outside of the laboratory. Typical environments where alcohol is present allow individuals to move about freely and encounter alcohol while also being exposed to many other stimuli. This dissertation sought to implement a novel approach to assessing attentional bias in …
Liking, Craving, And Attentional Bias In Non-Dependent Drinkers, David Lovett
Liking, Craving, And Attentional Bias In Non-Dependent Drinkers, David Lovett
Graduate Theses and Dissertations
The purpose of the present study was to better understand alcohol use problems by examining the effect of alcohol liking on alcohol attentional bias among non-dependent drinkers. An adapted model of Robinson and Berridge’s (1993) incentive-sensitization theory of addiction was proposed which theorized that manipulation of alcohol liking would produce alcohol attentional bias (assessed via visual probe task) among non-dependent drinkers. To test this adapted model, alcohol liking was manipulated and the effect on alcohol attentional bias was examined. Participants were 53 legal-age, college drinkers (Mage = 23.49; 32.1% female; 67.9% White Non-Hispanic). Participants completed measures of alcohol drink preference, …
Cross-Lagged Relations Between Motives And Substance Use: Can Use Strengthen Your Motivation Over Time?, Christine A. Lee, Karen J Derefinko, Heather A. Davis, Richard S. Milich, Donald R. Lynam
Cross-Lagged Relations Between Motives And Substance Use: Can Use Strengthen Your Motivation Over Time?, Christine A. Lee, Karen J Derefinko, Heather A. Davis, Richard S. Milich, Donald R. Lynam
Psychology Faculty Publications
Motives for substance use have garnered considerable attention due to the strong predictive utility of this construct, both in terms of use and problems associated with use. The current study examined the cross-lagged relations between alcohol use and motives, and marijuana use and motives over three yearly assessment periods in a large sample (N = 526, 48% male) of college students. The relations between substance use and motives were assessed at each time point, allowing for the examination of these inter-relations over time. Results indicated different trends based on the type of substance. For alcohol use, cross-lagged trends were …
Examining The Protective Effect Of Ethnic Identity On Drug Attitudes And Use Among A Diverse Youth Population, Tamika C. B. Zapolski, Sycarah Fisher, Devin E. Banks, Devon J. Hensel, Jessica Barnes-Najor
Examining The Protective Effect Of Ethnic Identity On Drug Attitudes And Use Among A Diverse Youth Population, Tamika C. B. Zapolski, Sycarah Fisher, Devin E. Banks, Devon J. Hensel, Jessica Barnes-Najor
Educational, School, and Counseling Psychology Faculty Publications
Ethnic identity is an important buffer against drug use among minority youth. However, limited work has examined pathways through which ethnic identity mitigates risk. School-aged youth (N = 34,708; 52 % female) of diverse backgrounds (i.e., African American (n = 5333), Asian (n = 392), Hispanic (n = 662), Multiracial (n = 2129), Native American (n = 474), and White (n = 25718) in grades 4–12 provided data on ethnic identity, drug attitudes, and drug use. After controlling for gender and grade, higher ethnic identity was associated with lower past month drug use …
Can We Talk?: Synergistic Effects Of Cognitive And Behavioral Frameworks To Address Substance Use And Abuse, Lauren Jaye Adams
Can We Talk?: Synergistic Effects Of Cognitive And Behavioral Frameworks To Address Substance Use And Abuse, Lauren Jaye Adams
USF Tampa Graduate Theses and Dissertations
Behavioral economic accounts of substance use have provided a novel framework to examine constraints that affect behaviorally driven outcomes. Several behavioral studies support the application of such frameworks to examine impulsive decision-making processes as well as how subjective reward influences substance use. Based on stimulus-response models, behavioral economic research often applies mathematical formulas to draw conclusions about behavioral outcomes. These mathematical formulas, while useful, largely ignore decades of cognitive psychology research that have examined state-based influences (e.g., mood, environment, motivational processes, etc.) on behavioral sequelae. To address this issue, the present study merged a cognitive framework into two behavioral economic …
Neurophysiological Capacity In A Working Memory Task Differentiates Dependent From Nondependent Heavy Drinkers And Controls, Michael J. Wesley, Joshua A. Lile, Mark T. Fillmore, Linda J. Porrino
Neurophysiological Capacity In A Working Memory Task Differentiates Dependent From Nondependent Heavy Drinkers And Controls, Michael J. Wesley, Joshua A. Lile, Mark T. Fillmore, Linda J. Porrino
Behavioral Science Faculty Publications
Background—Determining the brain-behavior profiles that differentiate heavy drinkers who are and are not alcohol dependent will inform treatment efforts. Working memory is linked to substance use disorders and can serve as a representation of the demand placed on the neurophysiology associated with cognitive control.
Methods—Behavior and brain activity (via fMRI) were recorded during an N-Back working memory task in controls (CTRL), nondependent heavy drinkers (A-ND) and dependent heavy drinkers (A-D). Typical and novel step-wise analyses examined profiles of working memory load and increasing task demand, respectively.
Results—Performance was significantly decreased in A-D during high working memory load …
How Parenting Style Relates To Adolescent Substance Abuse In An At-Risk Male Population, Bailee R. Brewer
How Parenting Style Relates To Adolescent Substance Abuse In An At-Risk Male Population, Bailee R. Brewer
Honors Theses
Parents have an important role in their children’s development. There is evidence that parenting behaviors such as parental involvement, monitoring of children, and inconsistent discipline play a role in adolescent substance use. The purpose of this study is to document perceptions of parenting behaviors among youth at a residential boot camp facility for at-risk adolescents, and to relate those perceptions to youths’ self-reported history of substance use. This study adds to previous research on parenting behavior by examining the parenting behaviors reported by troubled youth, rather than the more typically studied normative youth. Additionally, this study tests whether previously reported …
Curbing The Dui Offender's Self-Efficacy To Drink And Drive: A Laboratory Study, Walter Roberts, Mark T. Fillmore
Curbing The Dui Offender's Self-Efficacy To Drink And Drive: A Laboratory Study, Walter Roberts, Mark T. Fillmore
Psychology Faculty Publications
Background—People arrested for driving under the influence of alcohol (DUI) are at high risk to reoffend. One reason for this high rate of recidivism among DUI offenders is that these individuals systematically underestimate the degree to which alcohol impairs their ability to drive. This study compared perceived and objective driving ability following alcohol and performance feedback in drivers with and without a history of DUI.
Method—Adult drivers with (n = 20) and without (n = 20) a history of DUI arrest attended two dose challenge sessions where they received 0.64 g/kg alcohol or placebo, completed a simulated driving …
Internalizing And Externalizing Dysfunction: An Integrative Model Of Adolescent Drinking, Leila Guller
Internalizing And Externalizing Dysfunction: An Integrative Model Of Adolescent Drinking, Leila Guller
Theses and Dissertations--Psychology
Separate externalizing and internalizing pathways to problem drinking have been described. However, internalizing and externalizing are substantially correlated, thus, there is good reason to believe that these two forms of dysfunction behaviors do not operate independently.
We tested an integrative developmental model of transactions among internalizing symptomatology, externalizing personality, and psychosocial learning in the prediction of both drinking problems and future internalizing symptoms. To do so, we studied a large sample (n = 1910, 49.9% female) of children over a critical developmental period, from the spring of 5th (last year elementary school) grade through the spring of 9th grade (first …
Alcohol Use And Strenuous Physical Activity In College Students: A Longitudinal Test Of 2 Explanatory Models Of Health Behavior, Heather A. Davis, Elizabeth N. Riley, Gregory T. Smith, Richard S. Milich, Jessica L. Burris
Alcohol Use And Strenuous Physical Activity In College Students: A Longitudinal Test Of 2 Explanatory Models Of Health Behavior, Heather A. Davis, Elizabeth N. Riley, Gregory T. Smith, Richard S. Milich, Jessica L. Burris
Psychology Faculty Publications
Objective: To help clarify the effect of gender on the bidirectional relationship between alcohol use and strenuous physical activity in college students. Participants: Five hundred twenty-four (52% female) college students recruited in August 2008 and 2009 and followed up in April 2009 and April 2011, respectively. Methods: Participants reported their alcohol use and strenuous physical activity on 2 occasions (baseline and follow-up) spaced approximately 1 or 2 years apart. Results: For females, alcohol use quantity at baseline was associated with increased strenuous physical activity at 1- and 2-year follow-ups, and alcohol use frequency at baseline was …
Chronic Binge Alcohol Administration Dysregulates Hippocampal Genes Involved In Immunity And Neurogenesis In Simian Immunodeficiency Virus-Infected Macaques, John K Maxi, Matt Dean, Jovanny Zabaleta, Krzysztof Reiss, Gregory J. Bagby, Steve Nelson, Peter J. Winsauer, Francesca Peruzzi, Patricia E. Molina
Chronic Binge Alcohol Administration Dysregulates Hippocampal Genes Involved In Immunity And Neurogenesis In Simian Immunodeficiency Virus-Infected Macaques, John K Maxi, Matt Dean, Jovanny Zabaleta, Krzysztof Reiss, Gregory J. Bagby, Steve Nelson, Peter J. Winsauer, Francesca Peruzzi, Patricia E. Molina
School of Graduate Studies Faculty Publications
Alcohol use disorders (AUD) exacerbate neurocognitive dysfunction in Human Immunodeficiency Virus (HIV+) patients. We have shown that chronic binge alcohol (CBA) administration (13-14 g EtOH/kg/wk) prior to and during simian immunodeficiency virus (SIV) infection in rhesus macaques unmasks learning deficits in operant learning and memory tasks. The underlying mechanisms of neurocognitive alterations due to alcohol and SIV are not known. This exploratory study examined the CBA-induced differential expression of hippocampal genes in SIV-infected (CBA/SIV+; = 2) macaques in contrast to those of sucrose administered, SIV-infected (SUC/SIV+; = 2) macaques. Transcriptomes of hippocampal samples dissected from brains obtained at necropsy (16 …