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Full-Text Articles in Viruses

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh Jan 2023

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

Undergraduate Research Posters

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …


Oral History Interview: Josephine R. Gorby, Josephine R. Gorby Jul 1974

Oral History Interview: Josephine R. Gorby, Josephine R. Gorby

0064: Marshall University Oral History Collection

Josephine Gorby was born on February 24, 1908. She began her teaching career in a one-room school in Wimmer, McDowell County, WV. In 1931 she began teaching in Lawrence County, OH. Mrs. Gorby’s interview focuses on growing up on a farm near Proctorville, OH, her experiences as an educator, her family’s experience during World War I, and the 1937 flood of the Ohio River and its tributaries. In the audio clip provided, Mrs. Gorby discusses the impact of the 1937 flood on the school house in Athalia, OH. During her interview, she also focuses on the construction and use of …