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Recent Articles in Viruses

Characterization Of Antiviral Properties Of Trappin-2 And Elafin Against Hiv-1 And Hsv-2 In The Female Genital Mucosa, Anna Drannik McMaster University

Characterization Of Antiviral Properties Of Trappin-2 And Elafin Against Hiv-1 And Hsv-2 In The Female Genital Mucosa, Anna Drannik

Open Access Dissertations and Theses

Sexually transmitted infections (STIs), especially HIV/AIDS and HSV-2, continue to be a devastating burden on societies around the world. The close link between HSV-2 and HIV-1, the role of inflammation in driving these infections, and the limited success and availability of prophylactic and therapeutic measures underscore the need for continued search of alternative means of protection. Characterization of endogenous antimicrobials, especially those local to the female genital tract and actively regulating inflammatory and antiviral responses, could be beneficial for microbicidal trials. Although regulators of mucosal immunity, such as serine antiproteases, trappin-2 and elafin (Tr/E), have been associated with ...