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Full-Text Articles in Rheumatology
Biomechanical Loading As A Driver Of Synovial Neovascularization And Microvascular Dysfunction In Knee Osteoarthritis, Mckenzie Carter
Biomechanical Loading As A Driver Of Synovial Neovascularization And Microvascular Dysfunction In Knee Osteoarthritis, Mckenzie Carter
Electronic Thesis and Dissertation Repository
Synovial inflammation and biomechanical loading are independent risk factors for knee osteoarthritis (OA). However, the relationship between inflammatory and biomechanical factors, specifically if increased biomechanical loading causes synovial inflammation in OA (mechanoinflammation), is not well understood. The purpose of this thesis was to explore the associations of knee load during walking with features of synovial inflammation in knee OA. The knee adduction moment magnitude was associated with increased synovial vascularization and perivascular edema. Synovial fluid from OA patients with high knee adduction moments promoted endothelial cell migration in vitro. Late-stage knee OA synovial fluid caused endothelial monolayer hyperpermeability in …
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
Electronic Thesis and Dissertation Repository
Modic changes (MCs), defined as bone marrow lesions adjacent to the vertebral endplate seen on MRI, have been associated with back pain. There are different types of MCs, with different histopathological correlates. This community-based study sample comprised 110 men from the Twin Spine Study, with baseline, 5-year, and 15-year follow-up MRIs. Following training and reliability testing, 1320 endplates (T12-S1) were evaluated for MC presence, type, and dimensions at each time point. Results demonstrated that Type 2 Modic Changes (MC2) were the most common type, with approximately half located at the two lowest disc levels. However, Type 1 Modic Changes (MC1) …