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Full-Text Articles in Rheumatology
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
The Natural History Of Modic Changes - A 5- And 15-Year Follow-Up Study, Parnian Saremi
Electronic Thesis and Dissertation Repository
Modic changes (MCs), defined as bone marrow lesions adjacent to the vertebral endplate seen on MRI, have been associated with back pain. There are different types of MCs, with different histopathological correlates. This community-based study sample comprised 110 men from the Twin Spine Study, with baseline, 5-year, and 15-year follow-up MRIs. Following training and reliability testing, 1320 endplates (T12-S1) were evaluated for MC presence, type, and dimensions at each time point. Results demonstrated that Type 2 Modic Changes (MC2) were the most common type, with approximately half located at the two lowest disc levels. However, Type 1 Modic Changes (MC1) …