Rheumatology Commons^™

Acquired Factor Viii Deficiency Presenting As Gross Hematuria In A Hispanic, Pregnant Patient With Previously Undiagnosed Connective Tissue Disease, Christine Loftis, Emilia C. Dulgheru, Rosa White

School of Medicine Publications and Presentations

Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed connective tissue disease. *is article includes a literature review of pregnancy-related cases of acquired factor VIII deficiency. We also reviewed various therapeutic approaches for the management of the acquired factor inhibitor which include achieving hemostasis and elimination of the inhibitor via immunosuppressive agents. *is case report describes the rare presentation of acquired factor VIII deficiency …