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Connexin-32 Contributes To Radiation Resistance In Thyroid Follicles, Da-Thao Dinh Tran
Connexin-32 Contributes To Radiation Resistance In Thyroid Follicles, Da-Thao Dinh Tran
Loma Linda University Electronic Theses, Dissertations & Projects
The objective of this study was to examine the role of gap junctions in the radiation resistance of thyroid follicles. The question of whether gap junctional intercellular communication plays an important role in the “contact effect”, wherein cells in direct apposition are more resistant to the damaging effects of radiation, has been debated for years. We used the Fischer rat thyroid cell line (FRTL-5) to carry out our experiments. This thesis is divided into two parts: 1) characterization of gap junctional properties in FRTL-5 cells and, 2) exposure of these cells to radiation.
We found that, unlike primary thyroid cells, …