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Aged;; Disease Progression;; Female;; Follow-Up Studies;; Humans;; Macular Degeneration/ complications/diagnosis;; Male;; Middle Aged;; Ophthalmoscopy/ methods;; Retinal Drusen/ diagnosis/etiology;; Retinal Pigment Epithelium/ pathology;; Retrospective Studies;; Tomography
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Full-Text Articles in Ophthalmology
Photoreceptor Perturbation Around Subretinal Drusenoid Deposits As Revealed By Adaptive Optics Scanning Laser Ophthalmoscopy, Y. Zhang, X. Wang, E. B. Rivero, M. E. Clark, C. D. Witherspoon, R. F. Spaide, C. A. Girkin, C. Owsley, C. A. Curcio
Photoreceptor Perturbation Around Subretinal Drusenoid Deposits As Revealed By Adaptive Optics Scanning Laser Ophthalmoscopy, Y. Zhang, X. Wang, E. B. Rivero, M. E. Clark, C. D. Witherspoon, R. F. Spaide, C. A. Girkin, C. Owsley, C. A. Curcio
Journal Articles
PURPOSE: To describe the microscopic structure of photoreceptors impacted by subretinal drusenoid deposits, also called pseudodrusen, an extracellular lesion associated with age-related macular degeneration (AMD), using adaptive optics scanning laser ophthalmoscopy (AOSLO). DESIGN: Observational case series. METHODS: We recruited 53 patients with AMD and 10 age-similar subjects who had normal retinal health. All subjects underwent color fundus photography, infrared reflectance, red-free reflectance, autofluorescence, and spectral-domain optical coherence tomography (OCT). Subretinal drusenoid deposits were classified by a 3-stage OCT-based grading system. Lesions and surrounding photoreceptors were examined by AOSLO. RESULTS: Subretinal drusenoid deposits were found in 26 eyes of 13 patients …