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Full-Text Articles in Ophthalmology
Methods Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Methods Of Inhibiting Alu Rna And Therapeutic Uses Thereof, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.
Protection Of Cells From Alu-Rna-Induced Degeneration And Inhibitors For Protecting Cells, Jayakrishna Ambati, Valeria Tarallo
Protection Of Cells From Alu-Rna-Induced Degeneration And Inhibitors For Protecting Cells, Jayakrishna Ambati, Valeria Tarallo
Ophthalmology and Visual Science Faculty Patents
A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.
Compositions And Methods For Treating Retinal Degradation, Jayakrishna Ambati, Benjamin J. Fowler
Compositions And Methods For Treating Retinal Degradation, Jayakrishna Ambati, Benjamin J. Fowler
Ophthalmology and Visual Science Faculty Patents
The present disclosure relates to compositions and methods for treating retinal damage and/or retinal degradation. More specifically, this disclosure relates to methods for treating degradation of the retinal pigment epithelium by administering compositions comprising a nucleoside and/or a nucleoside or nucleotide reverse transcriptase inhibitor.