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Full-Text Articles in Ophthalmology
Ccr3 Inhibition For Ocular Angiogenesis And Macular Degeneration, Jayakrishna Ambati
Ccr3 Inhibition For Ocular Angiogenesis And Macular Degeneration, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.
Methods And Animal Model For Analyzing Age-Related Macular Degeneration, Jayakrishna Ambati
Methods And Animal Model For Analyzing Age-Related Macular Degeneration, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also provided is a Ccl2-deficient, Ccr2-deficient dual knockout mouse, which is a useful animal model for age-related macular degeneration.