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Full-Text Articles in Ophthalmology
Ccr3 Inhibition For Ocular Angiogenesis And Macular Degeneration, Jayakrishna Ambati
Ccr3 Inhibition For Ocular Angiogenesis And Macular Degeneration, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin (CCL11), eotaxin-2 (CCL24) or eotaxin-3 (CCL26) inhibits ocular angiogenesis.
Ultra-Small Rnas As Toll-Like Receptor-3 Antagonists, Jayakrishna Ambati
Ultra-Small Rnas As Toll-Like Receptor-3 Antagonists, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Provided are methods and compositions for the treatment or prevention of macular degeneration or other diseases or disorders associated with activation of TLR3. Administration of double stranded RNAs having a length of 22 nucleotides or less treats or prevents macular degeneration or other diseases or disorders associated with activation of TLR3 due to the ability of the RNAs to bind to but not activate TLR3. Furthermore, all double stranded RNAs (both targeted and non-targeted) of 22 nucleotides or less in length can bind to but not activate TLR3 and thereby treat or prevent such conditions. Also provided of a method …