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Defensins In Ocular Immunity, Minhao Wu
Defensins In Ocular Immunity, Minhao Wu
Wayne State University Dissertations
Corneal infection with P. aeruginosa results in corneal perforation in susceptible
B6, but not resistant BALB/c mice. This study explored their role mBD 1-4 in corneal
infection, and their potential synergy. Immunostaining and real-time RT-PCR data
demonstrated that their expression was either constitutive (mBD1 and mBD2) or
inducible (mBD3 and mBD4) in normal BALB/c and B6 corneas, and disparately
regulated in BALB/c vs B6 corneas after infection. Knock down studies using siRNA
treatment indicated that mBD2 and mBD3, but neither mBD1 nor mBD4, is required in
ocular defense. Moreover, in vivo studies demonstrated individual and combined effects
of mBD2 and …