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Zucker School of Medicine at Hofstra/Northwell
80 and over;; Alleles;; Complement Factor H/genetics;; Cross-Sectional Studies;; Female;; Gene-Environment Interaction;; Genotype;; Geographic Atrophy/diagnosis/ epidemiology/genetics;; Humans;; Male;; Ophthalmoscopy;; Prospective Studies;; Proteins/genetics;; Questionnaires;; Retinal Drusen/diagnosis/ epidemiology/genetics;; Risk Factors;; Tomography
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Full-Text Articles in Ophthalmology
Risk Factors Associated With Reticular Pseudodrusen Versus Large Soft Drusen, S. Boddu, M. D. Lee, M. Marsiglia, M. Marmor, K. B. Freund, R. T. Smith
Risk Factors Associated With Reticular Pseudodrusen Versus Large Soft Drusen, S. Boddu, M. D. Lee, M. Marsiglia, M. Marmor, K. B. Freund, R. T. Smith
Journal Articles
PURPOSE: To investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen without reticular pseudodrusen. DESIGN: Prospective case-case comparison. METHODS: In a clinical practice setting, patients with AMD were sequentially screened using clinical examination and scanning laser ophthalmoscopy imaging to prospectively identify subjects (n = 73) with the phenotypes of (1) reticular pseudodrusen without large soft drusen (n = 30) or (2) large soft drusen without reticular pseudodrusen (n = 43). Subjects were genotyped for 2 alleles associated with …