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- A2E (1)
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Articles 1 - 2 of 2
Full-Text Articles in Ophthalmology
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Ophthalmology and Visual Science Faculty Publications
Circulation is an important delivery method for both natural and synthetic molecules, but microenvironment interactions, regulated by endothelial cells and critical to the molecule's fate, are difficult to interpret using traditional approaches. In this work, we analyzed and predicted growth factor capture under flow using computer modeling and a three-dimensional experimental approach that includes pertinent circulation characteristics such as pulsatile flow, competing binding interactions, and limited bioavailability. An understanding of the controlling features of this process was desired. The experimental module consisted of a bioreactor with synthetic endothelial-lined hollow fibers under flow. The physical design of the system was incorporated …
Synthesis And Cyclic Voltammetry Of A2e, Elizabeth White, Willa Harper
Synthesis And Cyclic Voltammetry Of A2e, Elizabeth White, Willa Harper
Student Scholarship – Chemistry
As aging occurs, great exposure to light leads to the build-up of fluorescent materials called lipofuscin in the retinal pigment epithelial cells. This accumulation of lipofuscin is correlated to the progression of age related macular degeneration and other retinal dystrophies. No cure for macular degeneration has been found, so lipofuscin is of great interest. The lipofuscin has been associated with an increase in radiation intake and a loss of photoreceptors in the retina. The compound A2E is being studied in this project because it is frequently found in the lipofuscin. The goal of this project is to further characterize A2E …