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- Fibrosis (2)
- Ophthalmology (2)
- Anti-VEGF (1)
- Aqueous outflow resistance (1)
- Diabetes (1)
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- Diabetic macular edema (DME) (1)
- Diabetic retinopathy (1)
- Efficacy (1)
- Excess extracellular matrix (ECM) deposition (1)
- Glaucoma (1)
- Glaucoma surgery (1)
- Iatrogenic (1)
- Inflammation (1)
- Lucentis (1)
- Optic nerve (1)
- Panretinal photocoagulation (PRP) (1)
- Pascal (1)
- Phosphatase and Tensin Homolg (PTEN) (1)
- Ranibizumab (1)
- Resolution (1)
- Retina (1)
- Safety (1)
- Structural and functional changes (1)
- Trabecular meshwork (1)
- Transforming Growth Factor-β (TGFβ) (1)
- Wound healing (1)
Articles 1 - 3 of 3
Full-Text Articles in Ophthalmology
Modulation Of Inflammation Driven Wound Healing After Glaucoma Surgery, James J. Armstrong
Modulation Of Inflammation Driven Wound Healing After Glaucoma Surgery, James J. Armstrong
Electronic Thesis and Dissertation Repository
Dysregulated wound healing contributes to most currently unanswered ophthalmological morbidity. Opacification and structure altering contractures compromise the delicate ocular anatomy upon which ocular function and healthy vision are reliant. Glaucoma filtration surgery, corneal stromal injury, proliferative vitreoretinopathy and age-related macular degeneration are major contributors to ocular morbidity – all with myofibroblast transdifferentiation and pathognomonic scarring activity at their core.
This thesis aims to revaluate the means by which dysregulated ocular wound healing is combated with evidence describing a novel strategy to mitigate its effects. A translational approach was used. An initial retrospective analysis of over ten thousand glaucoma surgeries found …
A Clinico-Pathological Study Of The Structural And Functional Changes In The Retina And Optic Nerve Following Diabetic Retinopathy Treatments, Richard Filek
Electronic Thesis and Dissertation Repository
Diabetic retinopathy (DR) is the result of microvascular changes in the retina due to hyperglycemia which alter the blood-retinal barrier (BRB). The increased permeability of BRB results in the accumulation of extracellular fluid, the development of diabetic macular edema (DME) and capillary occlusion. Capillary occlusion results in retinal ischemia which increases vascular endothelial growth factor (VEGF) levels, increases vascular permeability and results in neovascularization in proliferative diabetic retinopathy (PDR) patients. The treatments clinically used for DR are panretinal photocoagulation (PRP) for PDR and injectable vascular endothelial growth factor inhibitors (anti-VEGFs) for DME.
The safety of PRP and anti-VEGF therapy on …
Regulation Of Phosphatase And Tensin Homolog Expression And Activity By Transforming Growth-Factor Beta In The Trabecular Meshwork Cells: Implications For Primary Open Angle Glaucoma, Nikoleta Tellios
Electronic Thesis and Dissertation Repository
Glaucoma is a multifactorial condition caused, in part, by fibrosis of the sieve-like trabecular meshwork (TM) tissue, which impedes drainage of aqueous humor (AH), leading to increased intraocular pressure and associated optic nerve damage and blindness. Fibrosis of the TM is mainly caused by the increased levels of active transforming growth factor-β 2 (TGFβ2) in the AH of glaucoma patients.
Previous reports have shown that TGFβ decreases the expression of Phosphatase and Tensin Homolog (PTEN) gene and that PTEN is a major regulator of ECM deposition. In this study we investigate the regulation of PTEN protein expression and …