Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
Articles 1 - 2 of 2
Full-Text Articles in Neurology
Mouse Embryo Development In The Presence Of Capsaicin, Carlos Santiago Villar-Gosalvez
Mouse Embryo Development In The Presence Of Capsaicin, Carlos Santiago Villar-Gosalvez
Theses and Dissertations in Biomedical Sciences
Capsaicin is the pungent agent found in hot peppers of the Capsicum genus. It is a potent neurotoxin that stimulates the degranulation and degeneration of C-afferent neurons. Capsaicin is widely used as a food condiment and medicine. Human exposure of capsaicin can exceed levels shown to be neurotoxic in laboratory animals. Additionally, capsaicin can cross the blood/placenta barrier and affect an embryo in utero. In order to assay the potential for toxicity to human embryos, mouse embryos were exposed to capsaicin and the effect of the capsaicin on embryo development was measured. Embryos were co-cultured in Krebs medium with 1% …
Quantal Mechanisms Underlying Stimulation-Induced Augmentation And Potentiation, Hong Cheng
Quantal Mechanisms Underlying Stimulation-Induced Augmentation And Potentiation, Hong Cheng
Electronic Theses and Dissertations
Repetitive stimulation of motor nerves causes an increase in the number of packets of transmitter ("quanta") that can be released in the ensuing period. This represents a type of conditioning, in which synaptic transmission may be enhanced by prior activity. Despite many studies of this phenomenon, there have been no investigations of the quantal mechanisms underlying these events, due to the rapid changes in transmitter output and the short time periods involved. To examine this problem, a method was developed in which estimates of the quantal release parameters could be obtained over very brief periods (3 s). Conventional microelectrode techniques …