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Full-Text Articles in Neurology
Long-Term Changes Of Functional Mri-Based Brain Function, Behavioral Status, And Histopathology After Transient Focal Cerebral Ischemia In Rats, Kenneth Sicard, Nils Henninger, Marc Fisher, Timothy Duong, Craig Ferris
Long-Term Changes Of Functional Mri-Based Brain Function, Behavioral Status, And Histopathology After Transient Focal Cerebral Ischemia In Rats, Kenneth Sicard, Nils Henninger, Marc Fisher, Timothy Duong, Craig Ferris
Nils Henninger
BACKGROUND AND PURPOSE: The relation between recovery of brain function and neurological status after clinical and experimental cerebral ischemia is incompletely characterized. We assessed the evolution of ischemic injury, behavioral status, and brain activity at acute to chronic periods after transient middle cerebral artery occlusion (tMCAO) in rats. METHODS: Male Sprague-Dawley rats were subjected to 20-minute tMCAO (n=10) or sham operation (n=10). Sensorimotor behavioral testing and multimodal (diffusion, perfusion, T2, and functional) MRI, as well as postmortem hematoxylin-eosin staining, were performed before and up to 21 days after tMCAO. MRI and histological parameters were evaluated in 5 regions of interest …
Spectacular Shrinking Deficit: Insights From Multimodal Magnetic Resonance Imaging After Embolic Middle Cerebral Artery Occlusion In Sprague-Dawley Rats, Nils Henninger, Kenneth Sicard, Marc Fisher
Spectacular Shrinking Deficit: Insights From Multimodal Magnetic Resonance Imaging After Embolic Middle Cerebral Artery Occlusion In Sprague-Dawley Rats, Nils Henninger, Kenneth Sicard, Marc Fisher
Nils Henninger
Almost no data is available on the serial changes in the brain after spectacular shrinking deficit (SSD) that may help understand this relatively rare clinical phenomenon. Quantitative diffusion-(DWI), perfusion-(PWI), T(1)-(T1WI), T(2)-weighted (T2WI), and functional magnetic resonance imaging (fMRI) were performed before, during, and up to 7 days after embolic middle cerebral artery occlusion (eMCAO) in male Sprague-Dawley rats (n=9). Region of interest (ROI) analysis was used to evaluate structural and functional MR signal changes within three ROIs defined by the apparent diffusion coefficient (ADC), cerebral blood flow (CBF) signatures, and final tissue viability. DWI, PWI, and T2WI lesion volumes were …