Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Allergy and Immunology (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Communication (1)
- Community Health and Preventive Medicine (1)
- Critical Care (1)
-
- Diseases (1)
- Emergency Medicine (1)
- Family Medicine (1)
- Family Practice Nursing (1)
- Health Communication (1)
- Health Services Administration (1)
- Health and Medical Administration (1)
- Immune System Diseases (1)
- Immunity (1)
- Immunology and Infectious Disease (1)
- Immunology of Infectious Disease (1)
- Immunopathology (1)
- Immunotherapy (1)
- Infectious Disease (1)
- Life Sciences (1)
- Medical Immunology (1)
- Medical Microbiology (1)
- Medical Sciences (1)
- Microbiology (1)
- Nursing (1)
- Nursing Administration (1)
- Other Medicine and Health Sciences (1)
Articles 1 - 2 of 2
Full-Text Articles in Internal Medicine
Effectiveness Of Antibiotic Stewardship For Healthcare Providers At Urgent Care Clinics, Helen T. Adewole
Effectiveness Of Antibiotic Stewardship For Healthcare Providers At Urgent Care Clinics, Helen T. Adewole
Electronic Theses and Dissertations
Antibiotics have revolutionized modern medicine; however, the overuse in urgent care and primary care significantly contributes to the global burden of infections resistant to available antimicrobial medicines. Approximately 30% of the antimicrobials prescribed in acute care settings are unnecessary. Patient demand for antibiotics has seemingly skyrocketed following the recent COVID-19 pandemic. Practitioners must be knowledgeable about antibiotic stewardship initiatives, such as the wait-and-see approach, to reduce antibiotic overuse and improve the trajectory of antibiotic resistance and patient health outcomes. The gap in practice was the limited awareness of scientific evidence-based tools to partner with patients and improve antibiotic prescription patterns. …
Development, Expansion And Role Of Myeloid-Derived Suppressor Cells In Post-Sepsis Immune Suppression, Tuqa Alkhateeb
Development, Expansion And Role Of Myeloid-Derived Suppressor Cells In Post-Sepsis Immune Suppression, Tuqa Alkhateeb
Electronic Theses and Dissertations
Myeloid-derived suppressor cells (MDSCs) numbers increase significantly in sepsis and are associated with high mortality rates. These myeloid cell precursors promote immunosuppression, especially in the late (post sepsis) stage. However, the mechanisms that underlie MDSC expansion and programming are not completely understood. To investigate these mechanisms, we used a cecal-ligation and puncture (CLP) mouse model of polymicrobial sepsis that progresses from an early/acute proinflammatory phase to a late/chronic immunosuppressive phase. Previous studies in our laboratory showed that microRNA (miR)-21 and miR-181b elevate levels of the transcription factor nuclear factor 1 (NFI-A) that promotes MDSC expansion. We report here that miR-21 …