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Full-Text Articles in Internal Medicine
Calpain-Mediated Protein Targets In Cardiac Mitochondria Following Ischemia–Reperfusion, Ling Li, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky, Belinda Willard, Qun Chen
Calpain-Mediated Protein Targets In Cardiac Mitochondria Following Ischemia–Reperfusion, Ling Li, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky, Belinda Willard, Qun Chen
Internal Medicine Publications
Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury during ischemia (ISC)–reperfusion (REP) by improving mitochondrial function. However, the protein targets of CPN1/2 activation during ISC–REP are unclear. CPN1/2 include a large subunit and a small regulatory subunit 1 (CPNS1). Genetic deletion of CPNS1 eliminates the activities of both CPN1 and CPN2. Conditional cardiomyocyte specific CPNS1 deletion mice were used in the present study to clarify the role of CPN1/2 activation in mitochondrial damage during ISC–REP with an emphasis on identifying the potential protein targets of CPN1/2. …