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A Comprehensive Meta-Analysis Of Stem Cell Therapy For Chronic Angina, Rahman Shah, Samuel B. Latham, Sajjad A. Khan, Muhammad Shahreyar, Inyong Hwang, Ion S. Jovin

Section of Internal Medicine

Background: A substantial proportion of patients with coronary artery disease do not achieve complete revascularization and continue to experience refractory angina despite optimal medical therapy. Recently, stem cell therapy has emerged as a potential therapeutic option for these patients. However, findings of individual trials have been scrutinized because of their small sample sizes and lack of statistical power. Therefore, we conducted an updated comprehensive meta-analysis of available randomized controlled trials (RCTs) with the largest sample size ever reported on this subject.
Hypothesis: In patients with chronic angina stem cell therapy improves clinical outcomes.
Methods: Scientific databases and websites were searched …