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Full-Text Articles in Hepatology
The Prevention Of Inflammatory-Related Liver Damage By Tamoxifen In Rats Given Fish Oil, Renae Haycraft
The Prevention Of Inflammatory-Related Liver Damage By Tamoxifen In Rats Given Fish Oil, Renae Haycraft
Journal of Undergraduate Research at Minnesota State University, Mankato
The focus of this research was to decrease inflammatory-related liver damage from tamoxifen in rats by adding fish oil to the diet. Tamoxifen causes a significant increase in inflammation of the liver. Inflammation increases with the production of prostaglandins by a metabolic pathway involving arachidonic acid. The metabolism of tamoxifen by the enzyme cytochrome P450 leads to an increase in the production of prostaglandins. The increased inflammation is proportional to lipid accumulation and ultimately lipid peroxidation in the liver. Resulting damage in humans includes hepatic steatosis (fatty liver), nonalcoholic steatohepatitis (NASH), and cirrhosis. Fish oils rich in omega-3 fatty acids, …