Hepatology Commons^™

Lifestyle And Biological Risk Factors For Liver Fibrosis In The Miami Adult Studies On Hiv (Mash) Cohort: An Hiv Infected And Hiv/Hcv Co-Infected Population, Tiffanie S. Stewart

FIU Electronic Theses and Dissertations

Liver disease is now a leading cause of non-AIDS related morbidity and mortality in people living with HIV (PLWH). The present study investigated the interplay between adverse lifestyle factors that are prevalent in PLWH, biological mediators of liver pathogenesis, and a non-invasive measure of liver fibrosis (FIB-4 index) in HIV mono- and HIV/HCV co-infected individuals.

The results of this investigation in the Miami Adult Studies of HIV (MASH) cohort show that the odds of liver fibrosis progression significantly increased over two years for HIV mono-infected participants who drank alcohol hazardously (OR 3.038, P=0.048), and had BMI ≥ 28kg/m^{2 …}