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Full-Text Articles in Hepatology
Expression Of The Non-Structural Proteins Ns3/4a Of The Hepatitis C Virus Using A Genetically Modified Vesicular Stomatitis Virus Vector System, Angela Ye Seul Kim
Expression Of The Non-Structural Proteins Ns3/4a Of The Hepatitis C Virus Using A Genetically Modified Vesicular Stomatitis Virus Vector System, Angela Ye Seul Kim
2016 Undergraduate Awards
Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver diseases. Despite advancements in the development of antivirals and efforts to combat HCV infections, there is currently no vaccine for HCV. Adopting traditional approaches to HCV vaccine development has been impractical due to the lack of reproducible cell culture systems that can support HCV replication. In this study, the New Jersey serotype of recombinant vesicular stomatitis virus (rVSVNJ) was used as the vector to express non-structural proteins NS3/4A of genotype 1a HCV for potential vaccine purposes. The rVSVNJ-GMM vector was genetically modified by changing glycine to …