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Full-Text Articles in Hematology
Platelet Glycoprotein Lib: Chromosomal Localization And Tissue Expression, Paul F. Bray, Jean-Philippe Rosa, Geoffrey I. Johnston, Donny T. Shiu, Richard G. Cook, Chris Lau, Yuet Wai Kan, Rodger P. Mcever, Marc A. Shuman
Platelet Glycoprotein Lib: Chromosomal Localization And Tissue Expression, Paul F. Bray, Jean-Philippe Rosa, Geoffrey I. Johnston, Donny T. Shiu, Richard G. Cook, Chris Lau, Yuet Wai Kan, Rodger P. Mcever, Marc A. Shuman
Cardeza Foundation for Hematologic Research
The GPIIb-IIIa complex functions as a receptor for cytoadhesive proteins on the platelet surface. Both GPIIb and GPIIIa are synthesized by a human erythroleukemia (HEL) cell line. We isolated several cDNA clones by screening a HEL cell cDNA library with an oligonucleotide derived from amino acid sequence of GPIIb. Nucleotide and amino acid sequences were determined from 703 bp of one of these clones. Amino acid sequence of purified platelet GPIIb peptides confirmed the identity of the clone. The cDNA encodes the carboxyl terminus of the large (a) subunit of GPIIb and all of the smaller (f6) subunit of GPIIb. …