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Endocrinology, Diabetes, and Metabolism Commons™
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Full-Text Articles in Endocrinology, Diabetes, and Metabolism
Strength Training Improves Muscle Quality And Insulin Sensitivity In Hispanic Older Adults With Type 2 Diabetes, Naomi Brooks, Jennifer E. Layne, Patricia L. Gordon, Ronenn Roubenoff, Miriam E. Nelson, Carmen Castaneda-Sceppa
Strength Training Improves Muscle Quality And Insulin Sensitivity In Hispanic Older Adults With Type 2 Diabetes, Naomi Brooks, Jennifer E. Layne, Patricia L. Gordon, Ronenn Roubenoff, Miriam E. Nelson, Carmen Castaneda-Sceppa
Carmen Castaneda-Sceppa
Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment –HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 …
Whole-Body And Muscle Protein Metabolism Are Not Affected By Acute Deviations From Habitual Protein Intake In Older Men: The Hormonal Regulators Of Muscle And Metabolism In Aging (Horma) Study, Kevin E. Yarasheski, Carmen Castaneda-Sceppa, Jiaxiu He, Miwa Kawakubo, Shalender Bhasin, Ellen F. Binder, E. Todd Schroeder, Ronenn Roubenoff, Stan P. Azen, Fred R. Sattler
Whole-Body And Muscle Protein Metabolism Are Not Affected By Acute Deviations From Habitual Protein Intake In Older Men: The Hormonal Regulators Of Muscle And Metabolism In Aging (Horma) Study, Kevin E. Yarasheski, Carmen Castaneda-Sceppa, Jiaxiu He, Miwa Kawakubo, Shalender Bhasin, Ellen F. Binder, E. Todd Schroeder, Ronenn Roubenoff, Stan P. Azen, Fred R. Sattler
Carmen Castaneda-Sceppa
Background: Acute deviations in protein intake before the quantification of protein kinetics in older humans may explain the controversy over the effects of older age on muscle protein synthesis and proteolysis rates. Objective: We hypothesized that an acute decrease in protein intake from the habitual intake is associated with lower muscle protein synthesis and higher proteolysis rates, whereas an acute increase in protein intake from the habitual intake is associated with higher muscle protein synthesis and lower proteolysis rates. Design: In 112 community-dwelling healthy men aged 65–90 y, we quantified resting whole-body [1,2-13C2]leucine kinetics, muscle mixed protein fractional synthesis rates …
N-Terminal Propeptide Of Type Iii Procollagen As A Biomarker Of Anabolic Response To Recombinant Human Gh And Testosterone, Shalender Bhasin (1953-), E. Jiaxiu He, Miwa Kawabuko, E. Todd Schroeder, Kevin Yarasheski, Gregory J. Opitek, Alise Reicin, Fabian Chen, Raymond Lam, Jeffrey A. Tsou, Carmen Castaneda-Sceppa, Ellen F. Binder, Stanley P. Azen, Fred R. Sattler
N-Terminal Propeptide Of Type Iii Procollagen As A Biomarker Of Anabolic Response To Recombinant Human Gh And Testosterone, Shalender Bhasin (1953-), E. Jiaxiu He, Miwa Kawabuko, E. Todd Schroeder, Kevin Yarasheski, Gregory J. Opitek, Alise Reicin, Fabian Chen, Raymond Lam, Jeffrey A. Tsou, Carmen Castaneda-Sceppa, Ellen F. Binder, Stanley P. Azen, Fred R. Sattler
Carmen Castaneda-Sceppa
Context: Biomarkers that predict musculoskeletal response to anabolic therapies should expedite drug development. During collagen synthesis in soft lean tissue, N-terminal propeptide of type III procollagen (P3NP) is released into circulation. We investigated P3NP as a biomarker of lean body mass (LBM) and muscle strength gains in response to testosterone and GH. Design: Community-dwelling older men received GnRH agonist plus 5 or 10 g testosterone gel plus 0, 3, or 5 μg recombinant human GH daily. P3NP levels were measured at baseline and wk 4, 8, 12, and 16. LBM and appendicular skeletal muscle mass (ASM) were measured by dual-energy …
Testosterone And Growth Hormone Improve Body Composition And Muscle Performance In Older Men, Fred R. Sattler, Carmen Castaneda-Sceppa, Ellen F. Binder, E. Todd Schroeder, Yin Wang, Shalender Bhasin (1953-), Miwa Kawabuko, Yolanda Stewart, Kevin Yarasheski, Jagadish Ulloor, Patrick Colletti, Ronenn Roubenoff, Stanley P. Azen
Testosterone And Growth Hormone Improve Body Composition And Muscle Performance In Older Men, Fred R. Sattler, Carmen Castaneda-Sceppa, Ellen F. Binder, E. Todd Schroeder, Yin Wang, Shalender Bhasin (1953-), Miwa Kawabuko, Yolanda Stewart, Kevin Yarasheski, Jagadish Ulloor, Patrick Colletti, Ronenn Roubenoff, Stanley P. Azen
Carmen Castaneda-Sceppa
Context: Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat. Objectives: We tested the hypothesis that physiological supplementation with testosterone and GH together improves body composition and muscle performance in older men. Design, Setting, and Participants: One hundred twenty-two community-dwelling men 70.8 ± 4.2 yr of age with body mass index of 27.4 ± 3.4 kg/m2, testosterone of 550 ng/dl or less, and IGF-I in lower adult tertile (≤167 ng/dl) were randomized to receive transdermal testosterone (5 or 10 g/d) during a Leydig cell clamp plus GH …
Treatment With Potassium Bicarbonate Lowers Calcium Excretion And Bone Resorption In Older Men And Women, Bess Dawson-Hughes, Susan S. Harris, Nancy J. Palermo, Carmen Castaneda-Sceppa, Helen M. Rasmussen, Gerard E. Dallal
Treatment With Potassium Bicarbonate Lowers Calcium Excretion And Bone Resorption In Older Men And Women, Bess Dawson-Hughes, Susan S. Harris, Nancy J. Palermo, Carmen Castaneda-Sceppa, Helen M. Rasmussen, Gerard E. Dallal
Carmen Castaneda-Sceppa
Context: Bicarbonate has been implicated in bone health in older subjects on acid-producing diets in short-term studies. Objective: The objective of this study was to determine the effects of potassium bicarbonate and its components on changes in bone resorption and calcium excretion over 3 months in older men and women. Design, Participants, and Intervention: In this double-blind, controlled trial, 171 men and women age 50 and older were randomized to receive placebo or 67.5 mmol/d of potassium bicarbonate, sodium bicarbonate, or potassium chloride for 3 months. All subjects received calcium (600 mg of calcium as triphosphate) and 525 IU of …