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Articles 1 - 3 of 3
Full-Text Articles in Dermatology
Rac1 P29s Regulates Pd-L1 Expression In Melanoma., Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, Andrew E. Aplin
Rac1 P29s Regulates Pd-L1 Expression In Melanoma., Ha Linh Vu, Sheera Rosenbaum, Timothy J. Purwin, Michael A. Davies, Andrew E. Aplin
Department of Cancer Biology Faculty Papers
Whole exome sequencing of cutaneous melanoma has led to the detection of P29 mutations in RAC1 in 5-9% of samples, but the role of RAC1 P29 mutations in melanoma biology remains unclear. Using reverse phase protein array analysis to examine the changes in protein/phospho-protein expression, we identified cyclin B1, PD-L1, Ets-1, and Syk as being selectively upregulated with RAC1 P29S expression and downregulated with RAC1 P29S depletion. Using the melanoma patient samples in TCGA, we found PD-L1 expression to be significantly increased in RAC1 P29S patients compared to RAC1 WT as well as other RAC1 mutants. The finding that PD-L1 …
Radiation Oncology – Fulfilling A Need For Research, Education, And Practice: Effectiveness Of Calendula Lotion For Radiation Dermatitis (Poster), Jennifer B. Bergenstock Bsn, Rn, Ocn, Sandra Frey Rn Msn Ocn, Erin Light Rn Bsn Ocn, Kathy Krause Rn Ocn, Sue Lewis Rn Ocn, Marisa Kauker Rn Bsn Ocn, Jenna Byorek Rn Bsn, Debra Knappenberger Rn Ocn, Mary T. Konek Rn, Ocn, Ba, Ruth Ocasio Lpn, Mary Lenahan Durnin Rn Msn Ocn, Charles Andrews Md, Jeanette Blauth Md, Alyson Mcintosh Md, Steven Perch Md, Robert G. Prosnitz Md, Mph, Dennis Sopka Md, Clinton Leinweber Do, Tracy Kichline Data Systems Analyst, Mandy Hendricks Rn Msn Ocn
Radiation Oncology – Fulfilling A Need For Research, Education, And Practice: Effectiveness Of Calendula Lotion For Radiation Dermatitis (Poster), Jennifer B. Bergenstock Bsn, Rn, Ocn, Sandra Frey Rn Msn Ocn, Erin Light Rn Bsn Ocn, Kathy Krause Rn Ocn, Sue Lewis Rn Ocn, Marisa Kauker Rn Bsn Ocn, Jenna Byorek Rn Bsn, Debra Knappenberger Rn Ocn, Mary T. Konek Rn, Ocn, Ba, Ruth Ocasio Lpn, Mary Lenahan Durnin Rn Msn Ocn, Charles Andrews Md, Jeanette Blauth Md, Alyson Mcintosh Md, Steven Perch Md, Robert G. Prosnitz Md, Mph, Dennis Sopka Md, Clinton Leinweber Do, Tracy Kichline Data Systems Analyst, Mandy Hendricks Rn Msn Ocn
Patient Care Services / Nursing
No abstract provided.
Re-Recurrent Dermatofibrosarcomaprotuberans Of The Chest Wall., Niaz Hussain, Mujtaba Zaki Naveed, Ghulam H
Re-Recurrent Dermatofibrosarcomaprotuberans Of The Chest Wall., Niaz Hussain, Mujtaba Zaki Naveed, Ghulam H
Section of Pulmonary & Critical Care
Dermatofibrosarcomaprotuberans is a rare, soft tissue tumour with high rate of recurrence. It is locally aggressive, with a low rate of metastasis. We describe the case of a 42 year old man who presented with a re-recurrent, large tumour situated on the anterior chest wall in the sternal region. We did a wide local excision and covered the resulting defect by using bilateral, pectoralis major myocutaneous flaps. Histopathology and immunohistochemical staining findings were consistent with the diagnosis of Dermatofibrosarcoma Protuberance. Post operatively the patient was treated with chemotherapy and radiotherapy.