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Articles 1 - 6 of 6
Full-Text Articles in Anesthesiology
Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma
Evaluating Anesthetic Protocols For Non-Human Primate Functional Neuroimaging, Megha Verma
Electronic Thesis and Dissertation Repository
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that can be used to measure a proxy of neural activity in vivo with high spatial specificity. One subject can be followed for a long period of time to assess changes in functional brain organization. However, fMRI is extremely sensitive to motion. The challenges of training non-human primates to reduce motion in an MRI scanner motivate the study of anesthesia which is commonly used to substitute for this training. In this thesis, I compare three different commonly used anesthetic protocols: isoflurane, propofol-fentanyl in combination, and fentanyl alone, to test which of …
Evaluation Of Perioperative Peripheral Nerve Injury In Cardiac Surgery Using A Novel Automated Ssep Monitoring Device, Satoru Fujii
Evaluation Of Perioperative Peripheral Nerve Injury In Cardiac Surgery Using A Novel Automated Ssep Monitoring Device, Satoru Fujii
Electronic Thesis and Dissertation Repository
INTRODUCTION: The high incidence of peripheral nerve injury (PNI) in conventional cardiac surgery (CCS) is believed to result from mechanical injury during sternotomy and/or retraction of the sternum. Minimally invasive cardiac surgery (MICS) is a newly developed type of cardiac surgery which does not require sternotomy or retraction of the sternum. Since surgery related PNI can lead to serious problems for both the patients and care providers, the incidence and details of PNI in cardiac surgery needs to be investigated. OBJECTIVE: To compare the degree of nerve injury in MICS and CCS using somatosensory evoked potential (SSEP) signals. …
Reducing Distortion – Identifying Areas To Improve The Quality Of Randomized Clinical Trials Published In Anesthesiology Journals, Jeffrey T.Y. Chow
Reducing Distortion – Identifying Areas To Improve The Quality Of Randomized Clinical Trials Published In Anesthesiology Journals, Jeffrey T.Y. Chow
Electronic Thesis and Dissertation Repository
Randomized clinical trials (RCTs) provide important evidence to inform clinical decision making; if these trials are of low quality, the resulting clinical decision will likely also be of low quality. The main purpose of this thesis was to conduct a series of methodological surveys that would identify potential areas of improvement in the quality of reporting for RCTs published in anesthesiology journals. Trial registration adequacy, adherence to CONSORT for Abstracts guidelines, and sample size calculation quality were all assessed, with a final chapter exploring the effect of industry funding on these methodological quality measures. While the results suggest improvement over …
Ultrasound Guided Motor Sparing Knee Blocks For Postoperative Analgesia Following Total Knee Arthroplasty, Olawale A. Sogbein
Ultrasound Guided Motor Sparing Knee Blocks For Postoperative Analgesia Following Total Knee Arthroplasty, Olawale A. Sogbein
Electronic Thesis and Dissertation Repository
Postoperative total knee arthroplasty (TKA) pain is severe and can inhibit patients’ rehabilitation. We devised a single injection motor sparing knee block (MSB) by targeting the adductor canal and lateral femoral cutaneous nerve with a posterior knee infiltration under ultrasound. Our primary objective was to evaluate the duration of the MSB compared to a standard periarticular infiltration (PAI) using time to first rescue analgesia as the end point. We randomized 82 patients undergoing TKA to receive either preoperative MSB or intraoperative periarticular infiltration. Duration of analgesia was significantly longer in the MSB group with a mean difference of 8.8 hours. …
Gait Analysis And Therapeutic Application Of Carbon Monoxide In A Rodent Model Of Complex Regional Pain Syndrome Type-1, Hussein Abdo
Gait Analysis And Therapeutic Application Of Carbon Monoxide In A Rodent Model Of Complex Regional Pain Syndrome Type-1, Hussein Abdo
Electronic Thesis and Dissertation Repository
Complex regional pain syndrome type-I (CRPS-I) is a debilitating pain disorder often occurring secondary to distal extremity trauma. Its pathophysiology is not well understood; however, microvascular dysfunction is proposed as an important factor in its development and maintenance. Using a rodent model, we tested an automated gait analysis system (CatWalk™) to examine functional changes. In addition, the use of carbon monoxide releasing molecule-3 (CORM-3), a compound known to be a potent vasodilator and anti-inflammatory agent, was also tested as a treatment of CRPS-I-like symptoms. Using the CatWalk™ system, we observed significant changes in gait parameters post-injury, several of which persisted …
Resting-State Functional Network Disruptions In A Rodent Model Of Mesial Temporal Lobe Epilepsy (Tle), Ravnoor Singh Gill
Resting-State Functional Network Disruptions In A Rodent Model Of Mesial Temporal Lobe Epilepsy (Tle), Ravnoor Singh Gill
Electronic Thesis and Dissertation Repository
Mesial temporal lobe epilepsy (TLE) is the most common form of drug-refractory epilepsy. The clinical application of non-invasively mapped networks using resting-state functional magnetic resonance imaging (rsfMRI) in humans has been rather limited due to heterogeneous (varying etiology, drugs, onset, latent period, etc.) patient groups. We employed a pharmacological (kainic acid) rodent model of TLE to measure the extent of functional network disruptions using rsfMRI, and study selected behaviors and olfactory to hippocampus transmission. Graph theoretical network modelling and analysis revealed significant increase in functional connectivity connectivity to the temporal lobe (hippocampus) in epileptic-rats compared to controls in the limbic …