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Full-Text Articles in Neurosciences
The Inflammatory Response After Ischemic Stroke: Targeting Β2 And Β1 Integrins, Danielle N. Edwards, Gregory J. Bix
The Inflammatory Response After Ischemic Stroke: Targeting Β2 And Β1 Integrins, Danielle N. Edwards, Gregory J. Bix
Sanders-Brown Center on Aging Faculty Publications
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the area of ischemia. In particular, leukocytes migrate toward areas of inflammation by use of integrins, particularly integrins β1 and β2. Integrins have been shown to be necessary for leukocyte adhesion and migration, and thus are of immediate interest in many inflammatory diseases, including ischemic stroke. In this review, we identify the main integrins involved in leukocytic migration following stroke (αLβ2 …