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Neurosciences Commons

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Full-Text Articles in Neurosciences

Physiological And Morphological Characterization Of Genetically Defined Classes Of Interneurons In Respiratory Rhythm And Pattern Generation In Neonatal Mice, Maria Cristina De Guzman Picardo Jan 2012

Physiological And Morphological Characterization Of Genetically Defined Classes Of Interneurons In Respiratory Rhythm And Pattern Generation In Neonatal Mice, Maria Cristina De Guzman Picardo

Dissertations, Theses, and Masters Projects

Breathing in mammals depends on an inspiratory-related rhythm that is generated by glutamatergic neurons in the preBotzinger complex (preBotC), a specialized site of the lower brainstem. Rhythm-generating preBotC neurons are derived from a single lineage that expresses the transcription factor (TF) Dbx1, but the cellular mechanisms of rhythmogenesis remain incompletely understood. to elucidate these mechanisms we comparatively analyzed Dbx1-expressing neurons (Dbx1 +) and Dbxl- neurons in the preBotC in knock-in transgenic mice. Whole-cell recordings in rhythmically active newborn mouse slice preparations showed that Dbx1 + neurons activate earlier in the respiratory cycle and discharge greater magnitude inspiratory bursts compared to …


Age-Related Changes In The Neural Correlates Of Interval Timing, Cutter Augustus. Lindbergh Jan 2012

Age-Related Changes In The Neural Correlates Of Interval Timing, Cutter Augustus. Lindbergh

Dissertations, Theses, and Masters Projects

No abstract provided.


Morphological Study Of Dbx1+ Respiratory Rhythm-Generating Neurons In Preboetzinger Complex In Neonatal Mice, Krishanthi Tharanga Harshani Weragalaarachchi Jan 2012

Morphological Study Of Dbx1+ Respiratory Rhythm-Generating Neurons In Preboetzinger Complex In Neonatal Mice, Krishanthi Tharanga Harshani Weragalaarachchi

Dissertations, Theses, and Masters Projects

No abstract provided.