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- Aggrecan (1)
- Arthritis (1)
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- Brain (1)
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Articles 1 - 3 of 3
Full-Text Articles in Neurosciences
Wernicke’S Area In Autism: Rsfmri Study, Sydney Osbarn
Wernicke’S Area In Autism: Rsfmri Study, Sydney Osbarn
Honors Theses
We investigated the functional connectivity of Wernicke’s Area and its right homologue (Planum Temporale) in individuals with Autism Spectrum Disorder (ASD) and typically developing individuals. We used resting state functional magnetic resonance imaging to analyze these areas in 145 participants from The University of Michigan via ABIDE. As a retest sample, we also used data from a University of Pittsburgh cohort. There is weakened functional connectivity between Wernicke’s Area and Planum Temporale in individuals with ASD as opposed to typically developing individuals. Participants with ASD did not have greater connectivity in other regions compared to the control group. Pragmatics, nonverbalism, …
Correlation Of Inflammation In Arthritis With The Myelination In The Brain, Anna Spears
Correlation Of Inflammation In Arthritis With The Myelination In The Brain, Anna Spears
Honors Theses
This study was conducted to investigate whether the influence of arthritis has an effect on the cerebral white matter. The project was performed at the South Oxford Campus, where diffusion tensor imaging (DTI) data was obtained from the Nathan Kline Institute-Rockland Sample (NKI- RS). Image processing was conducted using Functional Magnetic Resonance Imaging of Brain Software Library in which we obtained raw data to formulate Apparent Diffusion Coefficient (ADC), Axial Diffusivity (AD), Radial Diffusivity (RD), and Fractional Anisotropy. A one way Analysis of Covariance (ANCOVA) was performed to determine the significant difference between the history of arthritis on each of …
Regulating Neuronal Growth With Structurally Defined Glycans, Gabriella D. Hartman
Regulating Neuronal Growth With Structurally Defined Glycans, Gabriella D. Hartman
Honors Theses
Chondroitin sulfate proteoglycans (CSPGs) and keratan sulfate proteoglycans (KSPGs) play an important role in neural development. Aggrecan, a CSPG, operates in the neural extracellular matrix where it negatively regulates neurite outgrowth to prevent aberrant process formation. Unfortunately, this aggrecan or CSPG-rich/KSPG-rich barrier can also prevent neuronal regeneration, which contributes to the inability to repair brain and spinal cord injuries. Removal of CSPGs and KSPGs has been shown to increase neurite outgrowth. We extend these findings by testing the ability of structurally-defined glycans to outcompete aggrecan and allow neurite outgrowth. Our overall goal is to determine if there is a particular …