Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (2)
- Medical Neurobiology (2)
- Psychology (2)
- Social and Behavioral Sciences (2)
- Anatomy (1)
-
- Animal Sciences (1)
- Animal Structures (1)
- Animal Studies (1)
- Animals (1)
- Bioethics and Medical Ethics (1)
- Biological Psychology (1)
- Biostatistics (1)
- Comparative Psychology (1)
- Medical Cell Biology (1)
- Medical Pharmacology (1)
- Medical Physiology (1)
- Medical Specialties (1)
- Neurology (1)
- Neuroscience and Neurobiology (1)
- Organisms (1)
- Other Animal Sciences (1)
- Physical Sciences and Mathematics (1)
- Physiological Processes (1)
- Public Health (1)
- Statistical Methodology (1)
- Statistics and Probability (1)
- Keyword
-
- Astrobiology (1)
- Astrocyte (1)
- Bacteria (1)
- Brain decoding (1)
- Cetaceans (1)
-
- Chondroitin sulfate proteoglycan (1)
- Consciousness (1)
- Cross-validation (1)
- Dolphins (1)
- Electrical stimulation (1)
- Emotion (1)
- Incentive Contrast (1)
- Induction (1)
- Lacosamide (1)
- Likelihood ratio test (1)
- Motivation (1)
- Neural and Behavioral Relativity (1)
- Neurocan (1)
- Neyman-Pearson Lemma (1)
- Null hypothesis (1)
- Permutation test (1)
- Porpoises and whales (1)
- Reviews (1)
- Self-awareness (1)
- Spinal cord injury (1)
- Variety (1)
- Voltage-gated sodium channel (1)
- Wound healing (1)
- Publication
- File Type
Articles 1 - 7 of 7
Full-Text Articles in Neurosciences
Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff
Current Understanding Of The Mechanism Of Action Of The Antiepileptic Drug Lacosamide, Michael A. Rogawski, Azita Tofighy, H Steve White, Alain Matagne, Christian Wolff
Michael A. Rogawski
The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test. Attention was drawn to lacosamide because of its high oral potency and stereoselectivity. Lacosamide is also active in the 6 Hz seizure model but inactive against clonic seizures in rodents induced by subcutaneous pentylenetetrazol, bicuculline and picrotoxin. It is also ineffective in genetic models of absence epilepsy. At doses greater than those required to confer protection in the MES test, lacosamide inhibits behavioral and electrographic seizures in hippocampal kindled rats. It also effectively terminates …
Minding The Aging Brain: Are We Ready For Personalized Medicine?, Jason Karlawish, Robert C. Green
Minding The Aging Brain: Are We Ready For Personalized Medicine?, Jason Karlawish, Robert C. Green
Robert A. Green
No abstract provided.
Relative Reward Effects On Operant Behavior: Incentive Contrast,Induction And Variety Effects, Howard Cromwell
Relative Reward Effects On Operant Behavior: Incentive Contrast,Induction And Variety Effects, Howard Cromwell
Howard Casey Cromwell
Comparing different rewards automatically produces dynamic relative outcome effects on behavior. Eachnew outcome exposure is to an updated version evaluated relative to alternatives. Relative reward effectsinclude incentive contrast, positive induction and variety effects. The present study utilized a novelbehavioral design to examine relative reward effects on a chain of operant behavior using auditory cues.Incentive contrast is the most often examined effect and focuses on increases or decreases in behavioralperformance after value upshifts (positive) or downshifts (negative) relative to another outcome. Weexamined the impact of comparing two reward outcomes in a repeated measures design with three ses-sions: a single outcome and …
Cetaceans And Primates: Convergence In Intelligence And Self-Awareness, Lori Marino
Cetaceans And Primates: Convergence In Intelligence And Self-Awareness, Lori Marino
Lori Marino, PhD
Cetaceans (dolphins, porpoises and whales) have been of greatest interest to the astrobiology community and to those interested in consciousness and selfawareness in animals. This interest has grown primarily from knowledge of the intelligence, language and large complex brains that many cetaceans possess. The study of cetacean and primate brain evolution and cognition can inform us about the contingencies and parameters associated with the evolution of complex intelligence in general, and, the evolution of consciousness. Striking differences in cortical organization in the brains of cetaceans and primates along with shared cognitive capacities such as self-awareness, culture, and symbolic concept comprehension, …
Sensory Neurons Respond To Neurocan Knock-Down In Reactive Astrocytes, Umang Khandpur
Sensory Neurons Respond To Neurocan Knock-Down In Reactive Astrocytes, Umang Khandpur
Umang Khandpur, MD Candidate
A Comparison Of Four Electrical Stimulation Types On Staphylococcus Aureus Growth In Vitro, Harold Merriman, Chris Hegyi, Cheryl Albright-Overton, John Carlos, Robert Putnam, Janet Mulcare
A Comparison Of Four Electrical Stimulation Types On Staphylococcus Aureus Growth In Vitro, Harold Merriman, Chris Hegyi, Cheryl Albright-Overton, John Carlos, Robert Putnam, Janet Mulcare
Harold L. Merriman
We evaluated the efficacy of common electrical stimulation (ES) types on bacterial growth in vitro using clinically relevant conditions. Four types of ES-continuous microamperage direct current (µADC), high-voltage pulsed current (HVPC), low-voltage monophasic milliamperage pulsed current (LVMmAPC), and low-voltage biphasic milliamperage pulsed current (LVBmAPC)-were each applied to a separate set of culture plates containing Staphylococcus aureus for 1 h at 37 °C on 3 consecutive days. After ES treatment, the zone of inhibition surrounding each electrode was measured. Zone of inhibition measurements showed a significant inhibitory effect for continuous µADC and HVPC (p < 0.05), but not for LVMmAPC and LVBmAPC. …
Cross-Validation And Hypothesis Testing In Neuroimaging: An Irenic Comment On The Exchange Between Friston And Lindquist Et Al., Philip T. Reiss
Cross-Validation And Hypothesis Testing In Neuroimaging: An Irenic Comment On The Exchange Between Friston And Lindquist Et Al., Philip T. Reiss
Philip T. Reiss
The “ten ironic rules for statistical reviewers” presented by Friston (2012) prompted a rebuttal by Lindquist et al. (2013), which was followed by a rejoinder by Friston (2013). A key issue left unresolved in this discussion is the use of cross-validation to test the significance of predictive analyses. This note discusses the role that cross-validation-based and related hypothesis tests have come to play in modern data analyses, in neuroimaging and other fields. It is shown that such tests need not be suboptimal and can fill otherwise-unmet inferential needs.