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Sensory Neurons Respond To Neurocan Knock-Down In Reactive Astrocytes, Umang Khandpur
Sensory Neurons Respond To Neurocan Knock-Down In Reactive Astrocytes, Umang Khandpur
Umang Khandpur, MD Candidate
Spinal Cord Injury (SCI), in many cases due to trauma related events, is a potentially incapacitating affliction that can lead to immense physical, psychosocial and financial burdens for both individuals and society. Understanding the cellular and molecular changes that occur following SCI may lead to therapies for improved treatment. At the cellular level, contusive SCI often results in the formation of a glial (astrocyte) scar that blocks successful axonal regeneration, partly due to the up-regulation of inhibitory extracellular matrix (ECM) molecules like chondroitin sulfate proteoglycans (CSPGs). The long-term goal is to encourage neuroregeneration in vivo by targeting specific inhibitory CSPGs …