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Articles 1 - 9 of 9
Full-Text Articles in Neurosciences
Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen
Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen
Dissertations (1934 -)
Glutamatergic signaling is fundamental to human behavior and its dysfunction is implicated in a wide range of neurological and neurodegenerative disorders. Excitatory amino-acid transporters (EAATs) – of which four primary subtypes (EAAT1, EAAT2, EAAT3, and EAAT4) exist in the human brain – are primary regulators of glutamate signaling. Endogenously-expressed at either low (EAAT4-low) or high (EAAT4-high) concentration in cerebellar Purkinje cells, EAAT4 has been shown to regulate Purkinje cell activity in the cerebellar molecular layer. However, differences in glutamatergic signaling at the circuit and single-synaptic levels in EAAT4-low and EAAT4-high regions are poorly understood. To characterize EAAT4-specific effects on excitatory …
Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen
Eaat4-Dependent Effects On Glutamatergic Signaling In The Cerebellar Molecular Layer, Christopher Chen
Dissertations (1934 -)
Glutamatergic signaling is fundamental to human behavior and its dysfunction is implicated in a wide range of neurological and neurodegenerative disorders. Excitatory amino-acid transporters (EAATs) – of which four primary subtypes (EAAT1, EAAT2, EAAT3, and EAAT4) exist in the human brain – are primary regulators of glutamate signaling. Endogenously-expressed at either low (EAAT4-low) or high (EAAT4-high) concentration in cerebellar Purkinje cells, EAAT4 has been shown to regulate Purkinje cell activity in the cerebellar molecular layer. However, differences in glutamatergic signaling at the circuit and single-synaptic levels in EAAT4-low and EAAT4-high regions are poorly understood. To characterize EAAT4-specific effects on excitatory …
Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Aging, Executive Function, Fronto-Parietal Network Cortical Thickness: Insights From Cognitive Reserve, Katherine Reiter
Dissertations (1934 -)
Cognitive reserve (CR) indexes the nonlinear relationship between neurological insult and behavioral change. CR is manifested in both static factors (e.g., childhood environment, education) and modifiable lifestyle factors, (e.g., leisure activities). Detailed investigation of the influence of CR on cortical thickness, which indexes neuropathology, and cognitive functioning could be particularly important in understanding the heterogeneity of Alzheimer’s disease (AD). While memory decline is the hallmark of AD, executive functioning (EF) decline often predates memory changes, making EF an important target for investigating CR influences. The current study examines the relationship of CR and genetic risk for AD (ε4) on EF …
The Neural Encoding Of Reward In The Striatal-Pallidal Circuitry, Chung Lung Chan
The Neural Encoding Of Reward In The Striatal-Pallidal Circuitry, Chung Lung Chan
Dissertations (1934 -)
Humans and animals are constantly exposed to external stimuli. The ability to process reward value of a stimulus is critical to guiding appropriate behavior and essential for survival. These processes are regulated by neuronal activity and neurochemical signaling in the reward circuitry, particularly in the nucleus accumbens (NAc). The NAc receives dopaminergic inputs from the midbrain ventral tegmental area (VTA) and sends GABAergic projections to the ventral pallidum (VP). Electrophysiological studies have characterized phasic neuronal responses in the NAc that differential encode appetitive and aversive taste stimuli. Exposure to an appetitive taste stimulus evoked predominantly phasic inhibitory responses in the …
Regulation Of System Xc-By The Neuropeptide Pacap: Implications For Glutamate Transmission In Drug Addiction, Linghai Kong
Regulation Of System Xc-By The Neuropeptide Pacap: Implications For Glutamate Transmission In Drug Addiction, Linghai Kong
Dissertations (1934 -)
Drug addiction is a chronic brain disorder characterized by heightened relapse susceptibility. Drug-induced aberrant glutamate signaling in corticostriatal circuitry contributes to behaviors in virtually every preclinical model of drug seeking and correlates with drug craving in human. Here, we propose that glutamate signaling is a product of integrated activity between neurons and astrocytes, such that disruptions within astrocytes can stem from abnormal neuronal signaling (e.g., altered corticostriatal firing) and be the source of additional disruptions in other neuronal circuits. The astrocytic mechanism studied in these experiments is system xc- (Sxc) since drug-induced changes to this non-vesicular glutamate release mechanism contribute …
A Neurobiological Pathway That Mediates Stress-Induced Drug Use, Oliver Vranjkovic
A Neurobiological Pathway That Mediates Stress-Induced Drug Use, Oliver Vranjkovic
Dissertations (1934 -)
Cocaine addiction represents a tremendous health and financial burden on our society and the high rate of relapse to cocaine use in abstinent addicts represents a major barrier to effective therapy. Thus, understanding the factors that contribute to relapse and the underlying neurobiological processes is important for guiding the development of treatment for addiction. Stressful life events often trigger drug use in recovering addicts. The contribution of stress to drug use is problematic due to the unpredictable and often uncontrollable nature of stress. A growing literature indicates that norepinephrine and corticotropin releasing factor (CRF) in the brain play key roles …
The Relationship Of Spasticity And Impairments In Force Regulation And Neuromuscular Fatigue Post Stroke, Reivian Berrios Barillas
The Relationship Of Spasticity And Impairments In Force Regulation And Neuromuscular Fatigue Post Stroke, Reivian Berrios Barillas
Dissertations (1934 -)
Hyperreflexia that causes muscle spasticity may contribute to limitations in force regulation and walking ability post stroke. Additionally, neuromuscular fatigue may reduce force regulation, which is important because fatigue can assist to strengthen muscles that control walking. Hyperreflexia may be caused by cortical disinhibition that allows Ia afferents to amplify excitatory synaptic inputs to motoneuron pools. Cortical disinhibition is presumably caused by stroke-related motor cortex damage. Although, other excitatory synaptic sources to motoneurons contribute to motor control, hyperreflexia may be one contributor that affects stroke survivors. However, hyperreflexia is reported infrequently to effect force regulation post stroke. The goal was …
Neural Plasticity In Response To Intervention In Adolescents With Autism Spectrum Disorders, Sheryl Jayne Stevens
Neural Plasticity In Response To Intervention In Adolescents With Autism Spectrum Disorders, Sheryl Jayne Stevens
Dissertations (1934 -)
Current theories of Autism Spectrum Disorders (ASD) suggest that they may develop from the transactional interaction between biological risk factors and environmental processes (Dawson et al., 2009). Due to the brain’s experience-expectant nature, one’s degree of social exposure may have a significant impact on their brain development and behavioral presentation. In addition to the primary critical neurodevelopmental period identified in early childhood, recent research has demonstrated a second period of substantial neurodevelopment during the adolescent period (Sisk & Foster, 2004). This study investigated the neural and behavioral impact of participation in an empirically validated behavioral intervention (The Program for the …
Investigation Of Spatio-Temporal Effects Of Fmri Visual Field Mapping Techniques On V1, John J. Janik
Investigation Of Spatio-Temporal Effects Of Fmri Visual Field Mapping Techniques On V1, John J. Janik
Dissertations (1934 -)
Blood oxygenation level dependent functional magnetic resonance imaging has been used extensively for mapping the representation of the visual field within the human brain. Visual field mapping using fMRI has been used clinically to assess patients with cortical pathology and to plan surgical treatment impacting the visual system. The accuracy of fMRI-based visual field mapping methods needs to be better understood for clinical use. This accuracy can be important for presurgical mapping of brain function near a tumor resection site since inaccurate rendition of the underlying neural function could lead to inappropriate resection of viable brain tissue. The most widely …