Neurosciences Commons^™

The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty

Graduate College Dissertations and Theses

When dysregulated, neural systems important for fear behaviors can contribute to mental health disorders such as anxiety, phobias, and post-traumatic stress disorder (PTSD). In PTSD, a myriad of symptoms is possible, but a hallmark feature of the disorder is generalizing fear. This occurs when fear is experienced inappropriately in relation to the environment or circumstances. To study this behavior in rodent models, contextual fear conditioning is used. Contextual fear conditioning is a learning theory preparation where rodents are conditioned with an aversive stimulus such as foot-shock in one distinct context (A), while concurrently being exposed to a safe context (B). …