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Full-Text Articles in Neurosciences
Normative Analysis Of Individual Brain Differences Based On A Population Mri-Based Atlas Of Cynomolgus Macaques, Qiming Lv, Mingchao Yan, Xiangyu Shen, Jing Wu, Wenwen Yu, Shengyao Yan, Feng Yang, Kristina Zeljic, Yuequan Shi, Zuofu Zhou, Longbao Lv, Xintian Hu, Ravi Menon, Zheng Wang
Normative Analysis Of Individual Brain Differences Based On A Population Mri-Based Atlas Of Cynomolgus Macaques, Qiming Lv, Mingchao Yan, Xiangyu Shen, Jing Wu, Wenwen Yu, Shengyao Yan, Feng Yang, Kristina Zeljic, Yuequan Shi, Zuofu Zhou, Longbao Lv, Xintian Hu, Ravi Menon, Zheng Wang
Brain and Mind Institute Researchers' Publications
The developmental trajectory of the primate brain varies substantially with aging across subjects. However, this ubiquitous variability between individuals in brain structure is difficult to quantify and has thus essentially been ignored. Based on a large-scale structural magnetic resonance imaging dataset acquired from 162 cynomolgus macaques, we create a species-specific 3D template atlas of the macaque brain, and deploy normative modeling to characterize individual variations of cortical thickness (CT) and regional gray matter volume (GMV). We observed an overall decrease in total GMV and mean CT, and an increase in white matter volume from juvenile to early adult. Specifically, CT …