Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Neurosciences
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze
Theses and Dissertations (Comprehensive)
Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …