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Full-Text Articles in Neurosciences
The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty
The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty
Graduate College Dissertations and Theses
When dysregulated, neural systems important for fear behaviors can contribute to mental health disorders such as anxiety, phobias, and post-traumatic stress disorder (PTSD). In PTSD, a myriad of symptoms is possible, but a hallmark feature of the disorder is generalizing fear. This occurs when fear is experienced inappropriately in relation to the environment or circumstances. To study this behavior in rodent models, contextual fear conditioning is used. Contextual fear conditioning is a learning theory preparation where rodents are conditioned with an aversive stimulus such as foot-shock in one distinct context (A), while concurrently being exposed to a safe context (B). …
Glycogen Synthase Kinase-3Β: An Investigation Of The Novel Serine 389 Phosphorylation Site, Brendan Deegan Hare
Glycogen Synthase Kinase-3Β: An Investigation Of The Novel Serine 389 Phosphorylation Site, Brendan Deegan Hare
Graduate College Dissertations and Theses
Stress associated psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder affect a large proportion of the population. Reductions in the complexity of neuronal morphology and reduced neurogenesis are commonly observed outcomes following stress exposure in rodent models and may represent a mechanism for the reduced brain volume in stress sensitive regions such as the hippocampus observed in individuals diagnosed with stress associated disorders. Multiple lines of evidence suggest that glycogen synthase kinase (GSK)-B may play a role in the neurodegenerative phenotype observed following stress exposure. GSK3B is atypical in that it is inhibited by phosphorylation. This inhibitory phosphorylation …