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Relationships Between Age And White Matter Integrity In Children With Phenylketonuria, Erika M. Wesonga
Relationships Between Age And White Matter Integrity In Children With Phenylketonuria, Erika M. Wesonga
Arts & Sciences Electronic Theses and Dissertations
Objective: Phenylketonuria (PKU) is a hereditary metabolic disorder associated with cognitive compromise. Diffusion tensor imaging (DTI) has allowed detection of poorer microstructural white matter integrity in children with PKU, with decreased mean diffusivity (MD) in comparison with healthy children. However, very little research has been conducted to examine the trajectory of white matter development in this population. The present study investigated potential differences in the developmental trajectory of MD between children with early- and continuously-treated PKU and healthy children across a range of brain regions.
Methods: Children with PKU (n = 31, mean age = 12.2 years) were …