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Full-Text Articles in Neurosciences
Physiological And Morphological Characterization Of Genetically Defined Classes Of Interneurons In Respiratory Rhythm And Pattern Generation In Neonatal Mice, Maria Cristina De Guzman Picardo
Physiological And Morphological Characterization Of Genetically Defined Classes Of Interneurons In Respiratory Rhythm And Pattern Generation In Neonatal Mice, Maria Cristina De Guzman Picardo
Dissertations, Theses, and Masters Projects
Breathing in mammals depends on an inspiratory-related rhythm that is generated by glutamatergic neurons in the preBotzinger complex (preBotC), a specialized site of the lower brainstem. Rhythm-generating preBotC neurons are derived from a single lineage that expresses the transcription factor (TF) Dbx1, but the cellular mechanisms of rhythmogenesis remain incompletely understood. to elucidate these mechanisms we comparatively analyzed Dbx1-expressing neurons (Dbx1 +) and Dbxl- neurons in the preBotC in knock-in transgenic mice. Whole-cell recordings in rhythmically active newborn mouse slice preparations showed that Dbx1 + neurons activate earlier in the respiratory cycle and discharge greater magnitude inspiratory bursts compared to …