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Full-Text Articles in Medical Neurobiology
Recognition And Characterization Of Stage-Specific Oocyst/Sporozoite Antigens Of Toxoplasma Gondii By Human Antisera., Lloyd H. Kasper, Patricia L. Ware
Recognition And Characterization Of Stage-Specific Oocyst/Sporozoite Antigens Of Toxoplasma Gondii By Human Antisera., Lloyd H. Kasper, Patricia L. Ware
Dartmouth Scholarship
Human infection with Toxoplasma gondii is presumed due to the ingestion of either tissue cysts containing bradyzoites or oocyst/sporozoites that are excreted in the feces of infected cats. The incidence of human infection in the general population by either of these routes is unknown. We have previously described unique stage-specific oocyst/sporozoite antigens identified by murine hybridoma monoclonal antibodies. We obtained acute and convalescent antitoxoplasma antisera from patients in an epidemiologically well-documented outbreak of oocyst-transmitted infection associated with the ingestion of contaminated water. An enzyme-linked immunosorbent assay comparing equal numbers of tachyzoites (invasive stage) and oocyst/sporozoite (excreted stage) indicated that these …