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Full-Text Articles in Medical Neurobiology
Neuroendocrine Peptides Neuropeptide-Y (Npy) And Peptide-Yy (Pyy) Suppress Cl- Secretion And K+ Secretion In Guinea Pig Distal Colon Through Action At Y2-Receptors, Susan T. Halm, Jin Zhang, Dan R. Halm
Neuroendocrine Peptides Neuropeptide-Y (Npy) And Peptide-Yy (Pyy) Suppress Cl- Secretion And K+ Secretion In Guinea Pig Distal Colon Through Action At Y2-Receptors, Susan T. Halm, Jin Zhang, Dan R. Halm
Neuroscience, Cell Biology & Physiology Faculty Publications
Electrogenic Cl– and K+ secretion in isolated mucosa from guinea pig distal colon measured as short-circuit current (Isc) and transepithelial conductance (Gt) were stimulated by epinephrine (epi), prostaglandin-E2 (PGE2) and carbachol (CCh). neuropeptide-Y (NPY) and peptide-YY (PYY) inhibited by 60% Cl– secretion activated by either PGE2 or PGE2+CCh with EC50’s of 16nM and 6nM, respectively. Neither peptide markedly inhibited the transient component of the PGE2+CCh response. Immunoreactivity (IR) for NPY was present in enteric ganglia and in proximity with crypts. Basolateral membranes of …